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16485-10-2

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16485-10-2 Usage

General Description

Different sources of media describe the General Description of 16485-10-2 differently. You can refer to the following data:
1. Panthenol (also called pantothenol) is the alcohol analog of pantothenic acid (vitamin B5), and is thus a provitamin of B5. In organisms it is quickly oxidized to pantothenic acid. It is a viscous transparent liquid at room temperature. Panthenol is used as a moisturizer and to improve wound healing in pharmaceutical and cosmetic products. Panthenol is a multi-functional active ingredient that would be useful in most skin care formulations. Its efficacy has been substantiated in numerous peer-reviewed journals. The biologically active form of Panthenol, D-panthenol (EU), is the stable alcohol analogue of vitamin B5, pantothenic acid (EU), and is quickly converted to vitamin B5 (pantothenate) in the body. Pantothenic acid is present in all living cells and acts as an essential nutritional component due to its role in the formation of acetyl-co-enzyme A in the early stages of metabolism. The main role of acetyl-co-enzyme A is to provide activated acetic acid into the citric acid cycle (Krebs Cycle). This produces carbon dioxide, water, and energy. Co-enzyme A also transfers to other molecules such as Nacetyl-glucosamine (EU) and acetylcholine (EU) to help in the production of steroids and the synthesis of fatty acids. Coenzyme A also helps the body detoxify foreign substances.
2. Panthenol exists in two optically active forms, both of which are used in pharmaceutical preparations.

Uses

Different sources of media describe the Uses of 16485-10-2 differently. You can refer to the following data:
1. Panthenol, the active form of panthenol, is enzymatically cleaved to form pantothenic acid (Vitamin B5), which is an essential component of Coenzyme A that acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium. Due to its good penetration and high local concentrations, dexpanthanol is used in many topical products, such as ointments and lotions for treatment of dermatological conditions to relieve itching or promote healing. Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties. The vitamin ingredient Panthenol is valued in skin and hair care applications for its moisturizing properties. It has anti-inflammatory effects and soothes irritated and sensitive skin. For hair care application it is known for its humectant properties and its ability to improve the resistance of hair to mechanical stress.
2. vitamin B5 precursor, radioprotectant, antimalarial
3. panthenol (pro-vitamin B5) acts as a penetrating moisturizer. Panthenol appears to stimulate cellular proliferation and aid in tissue repair. Studies indicate that when topically applied, panthenol penetrates the skin and gets converted into pantothenic acid, a B complex vitamin. Such action could possibly influence the skin’s natural resources of pantothenic acid. It imparts a nonirritant, non-sensitizing, moisturizing, and conditioning feel and promotes normal keratinization and wound-healing. Panthenol protects the skin against sunburn, provides relief for existing sunburn, and enhances the natural tanning process. Panthenol’s humectant character enables it to hold water in the product or attract water from the environment, resulting in a moisturizing effect. It enhances skin suppleness, and claims are that it also acts as an anti-inflammatory agent. It is considered a non-comedogenic raw material.
4. DL-Panthenol is used in the topical treatment of skin disorders, such as minor irritations and skin burns. Also used in the strengthening and treatment of hair.

Mechanism of action

Pantothenic acid is a precursor of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions involving transfer of acetyl groups. The final step in the synthesis of acetylcholine consists of the choline acetylase transfer of acetyl group from acetylcoenzyme A to choline. Acetylcholine is the neurohumoral transmitter in the parasympathetic system and as such maintains the normal functions of the intestine. Decrease in acetylcholine content would result in decreased peristalsis and in extreme cases adynamic ileus. Panthenol is well absorbed into the skin and quickly converted into Pantothenic acid by oxidation. Pantothenic acid is distributed into the cells and is converted to Acetyl Coenzyme-A (Acetyl CoA) in the cells of the epidermis. Human being require Vitamin B5 to synthesize Acetyl CoA which is an essential mediator to many biochemical reactions that sustain life (maintenance and repair of all cells) and which breaks down fats, carbohydrates and proteins for carbon dioxide, water, and energy generation. Furthermore, it synthesis fatty acids and sphingolipids, for stratum corneum lipid layers and cell membrane integrity & fluidity.

Side effects

Panthenol is generally well tolerated. In rare cases, skin irritation and contact allergies have been reported. Generally, topical panthenol formulations were well tolerated with minimal risk of skin irritation or sensitization.

Flammability and Explosibility

Nonflammable

Check Digit Verification of cas no

The CAS Registry Mumber 16485-10-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,4,8 and 5 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 16485-10:
(7*1)+(6*6)+(5*4)+(4*8)+(3*5)+(2*1)+(1*0)=112
112 % 10 = 2
So 16485-10-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)

16485-10-2 Well-known Company Product Price

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  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (B25114)  DL-Panthenol, 99%   

  • 16485-10-2

  • 50g

  • 159.0CNY

  • Detail
  • Alfa Aesar

  • (B25114)  DL-Panthenol, 99%   

  • 16485-10-2

  • 250g

  • 496.0CNY

  • Detail
  • Alfa Aesar

  • (B25114)  DL-Panthenol, 99%   

  • 16485-10-2

  • 1000g

  • 2275.0CNY

  • Detail
  • USP

  • (1494501)  Panthenol,racemic  United States Pharmacopeia (USP) Reference Standard

  • 16485-10-2

  • 1494501-200MG

  • 4,662.45CNY

  • Detail

16485-10-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Panthenol

1.2 Other means of identification

Product number -
Other names 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Skin Conditioning Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16485-10-2 SDS

16485-10-2Related news

Colorimetric and fluorimetric methods for determination of Panthenol (cas 16485-10-2) in cosmetic and pharmaceutical formulation08/11/2019

Two methods are suggested for determination of panthenol. The first is colorimetric method where panthenol is subjected to alkaline hydrolysis; the resulting β-alanol is allowed to react with vanillin (Duquenois reagent) in presence of McIlvain buffer pH 7.5. The color developed is measured at ...detailed

Comparative Study of the Therapeutic Effect of Panthenol (cas 16485-10-2) Gel and Mebo Ointment on Metacarpal Wound Healing in Donkeys08/09/2019

Skin wounds represent an enormous clinical and financial problem in equine. The present study evaluated the effect of Panthenol gel and Mebo ointment on metacarpal wounds healing in donkeys. This experimental study was carried out on eighteen adult donkeys divided into three groups each of six d...detailed

16485-10-2Relevant articles and documents

Method For the Production of a Keratin-Binding Effector Molecule

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, (2009/04/24)

The invention relates to a method of producing keratin-binding effector molecules, and to intermediates and end-products of the method according to the invention and to the use of the keratin-binding effector molecules produced according to the invention in dermocosmetics. In addition, the invention relates to a method of applying dermocosmetically active ingredients to skin and/or hair and to a method of increasing the residence time of an active ingredient on skin and hair.

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