Convenient synthesis of novel nitrones: (Z)-4-amino-5-(hydroxyimino)-2,5-dihydro-1H-imidazole 3-oxides

Article abstract of DOI:10.3987/COM-08-11569

Highly functionalized derivatives of (Z)-4-amino-5-(hydroxyimino)-2,5-dihydro-1H-imidazole 3-oxide were first and conveniently synthesized by the reactions of 3,4-diaminoglyoxime with benzaldehyde derivatives in the presence of p-toluenesulfonic acid. The

Full text of DOI:10.3987/COM-08-11569

HETEROCYCLES, Vol. 78, No. 6, 2009
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HETEROCYCLES, Vol. 78, No. 6, 2009, pp. 1445 - 1452. © The Japan Institute of Heterocyclic Chemistry
Received, 4th October, 2008, Accepted, 9th February, 2009, Published online, 12th February, 2009
DOI: 10.3987/COM-08-11569
CONVENIENT SYNTHESIS OF NOVEL NITRONES: (Z)-4-AMINO-5-
(HYDROXYIMINO)-2,5-DIHYDRO-1H-IMIDAZOLE 3-OXIDES
Xue-Qin Cao,a Zhan-Xiong Li,b Wen-Xing Zhong,a Li-Hua Qiu,a and
Guo-Qiang Chenb*
a College of Chemistry, Chemical Engineering and Materials Science, Soochow
University, Suzhou 215123, P. R. China
b
College of Textile and Clothing Engineering, Soochow University, Suzhou
215021, P. R. China
*Corresponding author. Tel: +86-512-67162166; fax: +86-512-67246786
E-mail address: chenguojiang@suda.edu.cn
Abstract – Highly functionalized derivatives of (Z)-4-amino-5-(hydroxyimino)-
2,5-dihydro-1H-imidazole 3-oxide were first and conveniently synthesized by the
reactions of 3,4-diaminoglyoxime with benzaldehyde derivatives in the presence
of p-toluenesulfonic acid. The procedure represents an effective method to obtain
a new kind of nitrones.
INTRODUCTION
It is well known that nitrones are highly valuable intermediates in organic synthesis.1 They are usually
typical examples of 1,3-dipoles easily participating in cycloaddition reactions to provide various
heterocyclic five-membered ring systems,2 and chiral cyclic nitrones are recognized attractive synthons,
especially for optically active alkaloids and amino sugars.3 Furthermore, due to their stability of resulting
nitroxide radicals and ease of chemical modification,4 nitrones have a wide range of biological activity,5
and specific nitrones not only be helpful to understand age-related disease processes but serendipitously
have proven to be candidates for therapeutics in some cases.6 At the same time, the derivatives of
2,5-dihydro-1H-imidazole 3-oxide and corresponding nitroxyl radicals possess magnetism.7 On the other
hand, the derivatives of oximes of five-membered heterocyclic compounds with two heteroatoms play an
important role in antiviral property, for example, the oxime derivatives of imidazole have high fungicidal
and protozoacidal activity.8

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Many methods for the synthesis of imidazole-N-oxides have been reported, most of them are based on
condensation of aldehydes with N-monosubstituted hydroxylamines, or oxidation of secondary amines or
N,N-disubstituted hydroxylamines,9 but there is no examples of 3,4-diaminoglyoxime acted as amine to
synthesize imidazole-N-oxides. However, during the study of having attempted to synthesize bis-Schiff
bases from 3,4-diaminoglyoxime and 2 equivalents of 4-hydroxybenzaldehyde in the presence of
p-toluenesulfonic acid, we found that a novel imidazole-N-oxide was formed (Scheme 1), and the new
structure was reported recently.10 In order to study the novel method, we investigated the reactions of
3,4-diaminoglyoxime
2
with other benzaldehydes containing different substitutent than
4-hydroxybenzaldehyde (Scheme 2). Herein, we report the synthesis of the title compounds named as
(Z)-4-amino-5-(hydroxyimino)-2,5-dihydro-1H-imidazole 3-oxides from these new reactions, and the
reaction mechanism is also proposed.
Ar
Ar
OH
N
H
N
H2N
NH2
H
H
p-TsOH
N
N
+
O
Ar
N
HO N
N OH
Ar
NH2
HO N
N OH
O
Ar= 4-HO(C6H4)
Scheme 1. Reaction of 3,4-diaminoglyoxime and 4-hydroxybenzaldehyde
OHc
b
H
N
5
H
1 N
a H
Ar
H2N
NH2
p-TsOH
+
O
2
3
O
4
d
N
Ar
HO N
N OH
NH2
1
2
3a-h
3b: Ar= 2-HOC6H4;
3a: Ar= Ph;
3c: Ar= 4-MeC6H4; 3d: Ar= 2-MeOC6H4;
3e: Ar= 2-O2NC6H4; 3f: Ar= 3-O2NC6H4;
3g: Ar= 4-O2NC6H4; 3h: Ar= 2-Cl-5-O2NC6H3.
Scheme 2. Synthesis of (Z)-4-amino-5-(hydroxyimino)-2,5-dihydro-1H-imidazole 3-oxide
RESULTS AND DISCUSSION
3,4-Diaminoglyoxime 2 was prepared according to a literature method.11 During the study of the next
reactions of 3,4-diaminoglyoxime 2 with benzaldehyde derivatives in the presence of p-toluenesulfonic
acid, we found that if the aromatic aldehydes 1 have electron-donating group, for example, a hydroxyl or
methyl group, the yield was higher; if the aromatic aldehydes 1 have electron-withdrawing group, for
example, a nitro-group, even though the nitro-group was at the para-place to the carbonyl group which
makes the steric hindrance smallest, the reaction time was extended about seven times, and the quantities

HETEROCYCLES, Vol. 78, No. 6, 2009
1447
of aromatic aldehyde and p-toluenesulphonic acid were more, the yield was still lower than those having
electron-donating group. Selected results from the above reactions are presented in Table 1. It is visible
that the yields of 3b-d are higher than that of 3e-h.
On the basis of the above results, we put forward the reaction mechanism as follows: Firstly, the
protonated carbonyl carbon in benzaldehyde derivatives was attacked by the nitrogen atom in one of the
amino groups of 3,4-diaminoglyoxime 2, and the C=N bond was formed by deprotonation and
dehydrating one molecule of water. Subsequently, the nitrogen of the newly formed C=N bond was
protonated, then the carbon of the C=N bond was bonded with the nitrogen atom in the oxime group
which is linked to the other amino group of 3,4-diaminoglyoxime 2, and the five-membered heterocyclic
ring was formed. By deprotonation, the final products 3 were obtained. The whole process is shown in
Scheme 3. According to the mechanism, benzaldehydes having electron-withdrawing group will make the
carbonium ion less stable, so benzaldehydes having electron-donating group are more suitable for the
reaction, and the corresponding yields are higher.
Table 1. Synthesis of (Z)-4-amino-5-(hydroxyimino)-2,5-dihydro-1H-imidazole 3-oxides 3a-h
Yield
Ar
Time (h)
Comp.
(%)
67
85
72
70
63
66
65
67
Ph
6
3
3
3a
3b
3c
3d
3e
3f
2-HOC6H4
4-MeC6H4
2-MeOC6H4
2-O2NC6H4
3-O2NC6H4
4-O2NC6H4
2-Cl-5-O2NC6H3
4
22
22
28
28
3g
3h
Isolated yield.
H2N
HO N
NH2
H
H
NH2
NH2
H2N
H
HN
H
N OH
-H
H
HO
HO
O
OH
Ar
Ar
HO N
HO N
N OH
N OH
Ar
Ar
OH
N
OH
N
OH
N
OH
H
N
H
N
H
H
H
H
N
N
H
NH2
OH
N
N
N
-H2O
H
-H
H
H
Ar
Ar
Ar
Ar
N
N
Ar
NH2
N
HO
NH2
N
NH2
NH2
N
O
HO
OH
OH
Scheme 3. The plausible mechanism for the formation of (Z)-4-amino-5-(hydroxylimino)-2,5-
dihydro-1H-imidazole 3-oxide 3a-h

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HETEROCYCLES, Vol. 78, No. 6, 2009
The structures of products 3 are entirely different from bis-Schiff bases which we assumed at first by
3,4-Diaminoglyoxime reacted with 2 equivalents of benzaldehyde derivatives, but a heterocyclic
five-membered ring which is so-called 2,5-dihydro-1H-imidazole is formed. At the same time, the
nitrogen atom of the double bond is also bonded to an oxygen atom which is outside of the ring of
imidazole, so the products also belong to nitrones. Especially, in the structures of products 3, a
hydroxyimino group is directly linked to the ring of imidazole, which is the first example of this type of
compounds to our knowledge. The novel structures are highly functionalized besides a chiral carbon C2
by containing a hydroxyimino group, an amino group, a nitrogen-oxygen dipole and so on.
Formation of the (Z)-4-amino-5-(hydroxyimino)-2,5-dihydro-1H-imidazole 3-oxides structure was
unambiguously supported by spectroscopic and analytical data. A singlet at about  6 ppm in the 1H NMR
spectra was assigned to Ha bonded to the chiral carbon C2,  6.39-7.95 ppm to Hb of the imino group,
around  10 ppm to Hc of the hydroxyimino group,  5.58-7.02 ppm to Hd of the amino group, but the two
of former were occasionally observed as doublets. In the 13C NMR spectra, C2 appeared between 74.2 and
98.8 ppm, C4 and C5 resonated at 147.2 -163.7 ppm and 143.1-153.5 ppm, respectively. In addition, the
structure of 3e was also confirmed by X-ray crystallographic analysis as shown in Figure 1.
Figure 1. Crystal structure of 3e
It is worth to note that the peak number in the 13C NMR spectra is almost double as the number of carbon
atoms which might be due to a tautomerism of the hydroxyimino group (Scheme 4), but not all the same
1
in the H NMR spectra in all cases. Meanwhile, the peaks of active H are not always visible or only be
seen as small parts. Fortunately, we calculated the proportion of two isomers is about 10:5.5 from the
integral area in the 1H NMR spectra of 3a: the integral areas of the peaks at  5.77 and 5.61 ppm (Ha) are
1.29 and 0.73 respectively, at  7.82 and 6.39 ppm (Hb) are 1.08 and 0.59 respectively. Owing to the
sterical hindrance, the left isomer in Scheme 4 is predominant.

HETEROCYCLES, Vol. 78, No. 6, 2009
1449
c
OH
b
b
H
H
a
N
N
a
c
N
N
H
solvent
OH
H
Ar
Ar
d
NH2
d
N
N
NH2
O
O
Scheme 4. Tautomerism of the hydroxyimino group in products 3
In summary, we have used 3,4-diaminoglyoxime for the first time to react with benzaldehyde derivatives
to obtain nitrones. The synthesis complements other recognized methods and offers a novel kind of highly
functionalized nitrones named as (Z)-4-amino-5-(hydroxyimino)-2,5-dihydro-1H-imidazole 3-oxide in
good to excellent yields. Remarkably, this convenient and practical procedure does not require any
special handling, unusual reagents, and proceeds without the exclusion of air or water.
EXPERIMENTAL
Melting points were determined on a WRR apparatus and are uncorrected. Elemental analyses (C, H, N)
were performed on a EA1110 analyser. IR spectra were carried out on a Nicolet 5700 FTIR, using KBr
1
pellets. H NMR spectra were recorded on a Unity Inova 400 or Unity Inova 300 MHz spectrometer,
deuterated dimethylsulfoxide was used as the solvent, and tetramethylsilane (TMS) as the internal
standard. Chemical shift values are expressed as ppm downfield from TMS and J values are in Hz.
Splitting patterns are indicated as s: singlet, d: doublet, t: triplet, m: multiplet. 13C NMR spectra were also
recorded on a Unity Inova (300 MHz) spectrometer in deuterated dimethylsulfoxide using TMS as the
internal standard. Crystal data were collected on Rigaku Mercury CCD. All materials were obtained from
commercial suppliers and used without further purification.
General procedure for the synthesis and analytical data of 3a-h: A solution of 3,4-diaminoglyoxime
o
(1.475 g, 12.5 mmol) in anhydrous ethanol (150 mL) was heated to 55-65 C. Aromatic aldehyde
(12.5-15 mmol) and p-toluenesulphonic acid (0.625-1.125 mmol) were added and the resulting mixture
was stirred at this temperature. The progress of the reaction was monitored by TLC (MeOH/CHCl3 2:5).
After completion of the reaction, the solid product was collected by filtration and washed with anhydrous
ethanol or methanol several times. For further purification (if necessary), the above products were
recrystallized from a water-EtOH (1:2) or water-MeOH (1:4) mixture.
(Z)-4-Amino-5-(hydroxyimino)-2-phenyl-2,5-dihydro-1H-imidazole 3-oxide (3a): White solid, mp
179-180 oC (decomp.); IR (KBr, cm-1): 3360, 3251 (NH2), 3190, 3097 (OH), 2890 (the ring of imidazole),
1720, 1686 (C=N), 1600, 1460 (the ring of benzene), 1360 (N=O), 1230 (C-N), 959, 922 (N-O); 1H-NMR
(300 MHz, DMSO-d6):  5.61 (s, 1H, Hd), 5.77 (s, 1H, Hd), 6.39 (s, 1H, Hc), 6.50 (s,2H, Ha), 7.32-7.56 (m,

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HETEROCYCLES, Vol. 78, No. 6, 2009
13
10H, H-Ar), 7.82 (s, 1H, Hc), 10.05 (s, 1H, Hb); C-NMR (300 MHz, DMSO-d6): 85.3, 98.8, 132.2,
133.1, 133.6, 133.8, 134.5, 134.7, 142.5, 145.1, 146.9, 150.5, 153.5, 157.0; Anal. Calcd for C9H10N4O2: C,
52.42; H, 4.89; N, 27.17. Found: C, 52.25; H, 4.90; N, 27.21.
(Z)-4-Amino-5-(hydroxyimino)-2-(2-hydroxyphenyl)-2,5-dihydro-1H-imidazole 3-oxide (3b): Yield
o
(85%). White solid, mp 110-112 C (decomp.); IR (KBr, cm-1): 3414, 3330 (NH2), 3268, 3182 (OH),
2760 (the ring of imidazole), 1729, 1700 (C=N), 1609, 1464 (the ring of benzene), 1369 (N=O), 1230
1
(C-N), 959, 930 (N-O); H-NMR (300 MHz, DMSO-d6): 1.06 (t, J = 6.99 Hz, 6H), 3.44 (m, 4H,),
4.36(s, 2H), 5.58 (s, 2H, 2OH), 6.25 (d, J = 1.62 Hz, 1H, Ha), 6.66 (d, J = 1.36 Hz, 1H, Ha), 6.81-6.85 (m,
4H, H-Ar), 7.02 (s, 2H, Hd), 7.12 (d, J=1.38 Hz, 1H, Hb), 7.15-7.35 (m, 4H, H-Ar), 7.95 (d, J = 1.89 Hz,
13
1H, Hb), 10.16 (s, 1H, Hc), 10.23 (s, 1H, Hc); C-NMR (300 MHz, DMSO-d6): 24.0, 61.5, 81.5, 93.7,
120.8, 123.0, 124.2, 129.1, 130.6, 130.9, 132.4, 132.5, 135.4, 135.7, 143.4, 147.1, 149.8, 156.9, 160.8,
162.7; Anal. Calcd for C11H16N4O4: C, 49.25; H, 6.01; N, 20.88. Found: C, 49.17; H, 5.96; N, 21.09.
(Z)-4-Amino-5-(hydroxyimino)-2-(4-methylphenyl)-2,5-dihydro-1H-imidazole 3-oxide (3c): Yield
o
(72%). White solid, mp 182.5-184 C (decomp.); IR (KBr, cm-1): 3360, 3260 (NH2), 3190, 3097 (OH),
2880 (the ring of imidazole), 1720, 1686 (C=N), 1600, 1523, 1450 (the ring of benzene), 1360 (N=O),
1
1230 (C-N), 959, 928 (N-O); H-NMR (300 MHz, DMSO-d6):  2.32 (s, 6H, 2CH3), 5.59 (s, 1H, Ha),
5.71(s, 1H, Ha), 6.35 (s, 1H, one of Hd), 6.43 (s, 2H, Hd), 7.20-7.35 (m, 8H, H-Ar), 7.49 (s, 1H, Hb), 7.75
(s, 1H, Hb), 9.98 (s, 1H, Hc), 10.21 (s, 1H, Hc); 13C-NMR (300 MHz, DMSO-d6):  26.3, 85.2, 98.8, 132.2,
133.0, 134.1, 134.3, 139.5, 142.1, 142.2, 143.9, 144.1, 147.0, 150.6, 157.0; Anal. Calcd for C10H12N4O2:
C, 54.54; H, 5.49; N, 25.44. Found: C, 54.30; H, 5.63; N, 25.56.
(Z)-4-Amino-5-(hydroxyimino)-2-(2-methoxyphenyl)-2,5-dihydro-1H-imidazole 3-oxide (3d): White
o
solid, mp 181-182.5 C (decomp.); IR (KBr, cm-1): 3315, 3265 (NH2), 3182 (OH), 2892 (CH3), 1711,
1690 (C=N), 1604, 1494, 1469 (the ring of benzene), 1348 (N=O), 1273,1023 (Ar-O-C), 1223 (C-N), 930
1
(N-O); H-NMR (300 MHz, DMSO-d6):  3.80 (s, 3H, CH3), 5.58 (s, 2H, Ha), 6.66 (d, J = 1.97 Hz, 1H,
13
Hd), 7.04 (d, J = 8.10 Hz, 2H, H-Ar), 7.21(s, 1H, Hc), 7.40 (m, 2H, H-Ar), 10.16 (s, 1H, Hb); C-NMR
(300 MHz, DMSO-d6):  61.0, 61.3, 80.8, 93.5, 116.6, 117.0, 125.7, 125.8, 130.3, 132.2, 132.6, 133.3,
135.7, 135.8, 143.1, 147.0, 150.9, 156.8, 162.5, 163.7; Anal. Calcd for C10H12N4O3: C, 50.84; H, 5.12; N,
23.72. Found: C, 50.41; H, 5.25; N, 23.45.
(Z)-4-Amino-5-(hydroxyimino)-2-(2-nitrophenyl)-2,5-dihydro-1H-imidazole 3-oxide (3e): Yellow
solid, mp 191-193 oC (decomp.); IR (KBr, cm-1): 3350, 3251 (NH2), 3180, 3106 (OH), 2880 (the ring of
imidazole), 1700, 1677 (C=N), 1600, 1530, 1471 (the ring of benzene), 1350 (N=O), 1335 (NO2), 1240
(C-N), 976, 941 (N-O); 1H-NMR (400 MHz, DMSO-d6 ):  6.51 (s, 1H, Hd), 7.52 (dd, J = 7.81, 1.30 Hz,
1H, H-Ar), 7.67 (dt, J = 8.09, 8.08, 1.40 Hz, 1H, H-Ar), 7.79 (dt, J = 7.58, 7.57, 0.93 Hz, 1H, H-Ar),
13
8.03 (dd, J = 8.11, 1.06 Hz, 1H, H-Ar); C-NMR (300 MHz, DMSO-d6 ): 80.5, 94.2, 129.3, 130.2,

HETEROCYCLES, Vol. 78, No. 6, 2009
1451
133.2, 133.6, 135.7, 136.1, 139.1, 139.5, 140.2, 142.8, 143.4, 146.7, 150.4, 152.8, 155.1, 156.6; Anal.
Calcd for C9H9N5O4: C, 43.03; H, 3.61; N, 27.88. Found: C, 43.04; H, 3.63; N, 27.92.
(Z)-4-Amino-5-(hydroxyimino)-2-(3-nitrophenyl)-2,5-dihydro-1H-imidazole 3-oxide (3f): Yield
o
(66%), Yellow solid, mp 190-192 C (decomp.); IR (KBr, cm-1): 3422, 3350, 3243 (NH2), 3180, 3097
(OH), 2880 (the ring of imidazole), 1720, 1686 (C=N), 1600, 1540, 1455 (the ring of benzene), 1350
1
(N=O), 1318 (NO2), 1230 (C-N), 942, 916 (N-O); H-NMR (400 MHz, DMSO-d6): δ 6.01 (s, 1H, Ha),
7.73 (t, J = 7.88, 1H, H-Ar), 7.85 (d, J = 7.58 Hz, 1H, H-Ar), 8.21 (s, 1H, H-Ar), 8.28 (d, J = 8.06 Hz,
1H, H-Ar); 13C-NMR (300 MHz, DMSO-d6):  92.3, 121.5, 121.8, 124.2, 124.7, 130.7, 131.0, 134.0,
136.4, 142.0, 142.9, 144.8, 145.5, 148.6, 148.8, 149.0, 152.2; Anal. Calcd for C9H9N5O4: C, 43.03; H,
3.61; N, 27.88. Found: C, 42.97; H, 3.62; N, 27.94.
(Z)-4-Amino-5-(hydroxyimino)-2-(4-nitrophenyl)-2,5-dihydro-1H-imidazole 3-oxide (3g): Yield
o
(65%). Yellow solid, mp 192-194 C (decomp.); IR (KBr, cm-1): 3390, 3311 (NH2), 3251, 3170 (OH),
2910 (the ring of imidazole), 1690 (C=N), 1609, 1520, 1463 (the ring of benzene), 1350 (N=O), 1309
(NO2), 1240 (C-N), 968, 933 (N-O); 1H-NMR (400 MHz, DMSO-d6): δ 5.98 (s, 1H, Ha), 7.64 (d, J = 8.46
13
Hz, 2H, H-Ar), 8.27 (d, J = 8.47 Hz, 2H, H-Ar); C-NMR (300 MHz, DMSO-d6):  74.2, 74.3, 124.0,
124.4, 124.7, 124.9, 125.3, 125.4, 128.6, 129.4, 131.2, 131.4, 148.6, 150.2, 150.8, 151.3, 151.5, 152.8;
Anal. Calcd for C9H9N5O4: C, 43.03; H, 3.61; N, 27.88. Found: C, 42.91; H, 3.65; N, 27.90.
(Z)-4-Amino-5-(hydroxyimino)-2-(2-chloro-5-nitrophenyl)-2,5-dihydro-1H-imidazole 3-oxide (3h):
o
Yield (67%). Yellow solid, mp 201-203 C (decomp.); IR (KBr, cm-1): 3420, 3362, 3251 (NH2), 3166,
3080 (OH), 2704 (the ring of imidazole), 1712, 1690 (C=N), 1610, 1520, 1472 (the ring of benzene),
1350 (N=O), 1327 (NO2), 1230 (C-N), 950, 924 (N-O); 1H-NMR (400 MHz, DMSO-d6 ): δ 6.30 (d, J =
2.19 Hz, 1H, Ha), 6.72 (s, 2H, Hd), 7.82 (d, J = 8.84 Hz, 1H, H-Ar), 7.83 (d, J = 2.20 Hz, 1H, Hb), 8.07 (d,
J = 2.78 Hz, 1H, H-Ar), 8.27 (dd, J = 8.79, 2.81 Hz, 1H, H-Ar), 10.19 (s, 1H, Hc); 13C-NMR (300 MHz,
DMSO-d6 ): δ 77.5, 90.0, 123.2, 125.0, 126.2, 126.3, 132.2, 136.6, 139.3, 139.7, 141.3, 141.9, 142.7,
143.5, 145.5, 145.6, 147.2, 152.1; Anal. Calcd for C9H8N5O4Cl: C 37.84; H 2.82; N 24.52. Found: C
38.02; H 2.91; N 24.52.
The X-ray data for (Z)-4-amino-5-(hydroxyimino)-2-(2-nitrophenyl)-2,5-dihydro-1H-imidazole
3-oxide (3e): C9H9N5O4, Mw = 251.21, triclinic, space group P-1 / (#2), a = 7.6372(17), b = 7.8628(15), c
= 10.0673(15) Å, β = 106.261(19) deg, V = 533.14(18) Å3, Z = 2, Dcalc. = 1.565 g/cm3, μ (Mo-Kα) =
1.24cm-1, 5228 independent reflections, 166 parameters, R = 0.0787, Rw = 0.2242, T = 293(2) K.
Crystallographic data excluding structure have been deposited with the Cambridge Crystallographic Data
Center as supplementary publication numbers CCDC 703896. A copy of the data can be obtained free of
charge from CCDC, 12 Union road, Cambridge CB2 1EZ. UK [DIRECT LINE: +44 1223 762910, Fax:

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+44 1223 336033 or e-mail: linstead@ccdc.cam.ac.uk; deposit@ccdc.cam.ac.uk].
REFERENCES
1. (a) E. Colacino, P. Nun, F. M. Colacino, J. Martinez, and F. Lamaty, Tetrahedron, 2008, 64, 5569;
(b) W. Benchouk and S. M. Mekelleche, J. Mol. Struct. THEOCHEM, 2008, 852, 46.
2. N. Coskun and B. Yilmaz, Synth. Commun., 2004, 34, 1617.
3. L. Fisera, ‘Topics in Heterocyclic Chemistry: 1,3-Dipolar Cycloadditions of Sugar-Derived Nitrones
and their Utilization in Synthesis,’ Vol. 7, ed. by R. R. Gupta, Springer-Verlag, Berlin, Heidelberg,
2007, pp. 287-323.
4. L.-C. Li, D.-Z. Liao, L.-J. Bai, Z.-H. Jiang, and S.-P. Yan, J. Mol. Struct., 2001, 569, 179.
5. (a) M. A. Voinov, I. A. Grigorev, and L. B. T Volodarsky, Tetrahedron, 2000, 56, 4071; (b) A. R.
Green, T. Ashwood, T. Odergren, and D. M Jackson, Pharmacol. Ther., 2003, 100, 195; (c) N.
Coskun, H. Mert, and N. Arikan, Tetrahedron, 2006, 62, 1351.
6. R. A Floyd, Dieases Aging Cell., 2006, 5, 51.
7. (a) G. I Roschupkina, T.V. Rybalova, Yu. V. Gatilov, and V. A Reznikov, J. Struct. Chem., 2004, 45,
356; (b) L. Catala, R. Feher, D. B. Amabilino, K. Wurst, and J. Veciana, Polyhedron, 2001, 20, 1563;
(c) H. Oshio, M. Yamamoto, N. Hoshino, and T. Ito, Polyhedron, 2001, 20, 1621.
8. E. Abele, R. Abele, and E. Lukevics, Chem. Heterocyl. Comp., 2007, 43, 945.
9. (a) N. Coskun and D. Sumengen, Synth. Commun., 1993, 23, 1699; (b) N. Coskun, F. T. Tat, and O.
O. Guven, Tetrahedron, 2001, 57, 3413; (c) V. V. Martin and L. B. Volodarskii, Khim. Geterotsikl.
Soedin., 1979, 1, 103; (d) I. A. Grigorev, G. I. Shchukin, V. V. Martin, and V. I Mamatyuk, Khim.
Geterotsikl. Soedin., 1985, 2, 252; (e) G. I. Shchukin, I. A. Grigorev, and L. B Volodarskii, Khim.
Geterotsikl. Soedin., 1990, 4, 478; (f) N. Coskun and M. Ay, Heterocycles, 1998, 48, 537; (g) N.
Coskun, Tetrahedron, 1997, 53, 13873; (h) S. A. Popov, R. V. Andreev, G. V. Romanenko, V. I.
Ovcharenko, and V. A. Reznikov, J. Mol. Struct., 2004, 697, 49; (i) K. S. Chan, W. L. Yeung, W. K.
Chan, R.-J. Wang, and T. C.W. Mak, J. Org. Chem., 1995, 60, 1741; (j) Y. B. Han, B. Tuccio, R.
Lauricella, A. Rockenbauer, J. L. Zweier, and F. A. Villamena, J. Org. Chem., 2008, 73, 2533.
10. X.-Q. Cao, Z.-X. Li, G.-Q. Chen, and D.-C. Zhang, Acta Cryst., 2007, C63, 671.
11. K. Z. Alexander and L. T. Mark, Heterocyclic Chem., 1997, 34, 1057.