Horner Synthesis of Didehydroamino Acid Derivatives in a Liquid-Liquid Two-Phase System

DOI: 10.1055/s-1988-27493

Source and publish data:

Synthesis p. 140 - 142 (1988)

Update date:2022-08-04

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Authors:

Ciattini, Pier Giuseppe

Morera, Enrico

Ortar, Giorgio

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Article abstract of DOI:10.1055/s-1988-27493

Horner olefination of aldehydes 1 with N-acyl-2-(diethoxyphosphoryl)glycin ethyl esters 2 to give didehydroamino acid derivatives 3 can be performed advantageously in a 20percent aqueous sodium hydroxide/dichloromethane two-phase system in the absence of any typical phase-transfer catalyst.

Full text of DOI:10.1055/s-1988-27493

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