Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S′ subsite binding

DOI: 10.1016/j.bmc.2009.04.011

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Bioorganic and Medicinal Chemistry p. 3536 - 3542 (2009)

Update date:2022-09-26

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Authors:

Li, Yi Li, Yi

Dou, Dengfeng

He, Guijia

Lushington, Gerald H.

Groutas, William C.

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Article abstract of DOI:10.1016/j.bmc.2009.04.011

A series of mechanism-based inhibitors designed to interact with the S′ subsites of serine proteases was synthesized and their inhibitory activity toward the closely-related serine proteases human neutrophil elastase (HNE) and proteinase 3 (PR 3) was inve

Full text of DOI:10.1016/j.bmc.2009.04.011

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