Synthesis and Hypocholesterolemic Activity of 6,7-Dihydro-4H-pyrazolopyrrolopyrimidine-5,8-diones, Novel Inhibitors of AcylCoA:Cholesterol O-Acyltransferase

DOI: 10.1021/jm00109a028

Source and publish data:

Journal of Medicinal Chemistry p. 1721 - 1727 (1991)

Update date:2022-08-03

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Authors:

Larsen, Scott D.

Spilman, Charles H.

Bell, Frank P.

Dinh, Dac M.

Martinborough, Esther

Wilson, Gracella J.

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Article abstract of DOI:10.1021/jm00109a028

A novel series of 6,7-dihydro-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione inhibitors of the enzyme acylCoA:cholesterol O-acyltransferase is described.A number of these derivatives were found to be potent modulators of serum lipoprotein levels in

Full text of DOI:10.1021/jm00109a028

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