Journal of Medicinal Chemistry p. 1721 - 1727 (1991)
Update date:2022-08-03
Topics:
Larsen, Scott D.
Spilman, Charles H.
Bell, Frank P.
Dinh, Dac M.
Martinborough, Esther
Wilson, Gracella J.
A novel series of 6,7-dihydro-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione inhibitors of the enzyme acylCoA:cholesterol O-acyltransferase is described.A number of these derivatives were found to be potent modulators of serum lipoprotein levels in
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