Synthesis and antihepatotoxic activity of 2-(substituted-phenyl)-5-(2,3- dihydro-1,4-benzodioxane-2-yl)-1,3,4-oxadiazole derivatives

DOI: 10.3109/14756366.2010.489899

Source and publish data:

Journal of Enzyme Inhibition and Medicinal Chemistry p. 216 - 221 (2011)

Update date:2022-08-04

Topics:

Authors:

Ahmed, Bahar

Habibullah

Khan, Shamshir

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Article abstract of DOI:10.3109/14756366.2010.489899

Novel 1,3,4-oxadizole derivatives containing the 1,4-dioxane ring system were synthesised starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesised compounds were evaluated for antihepatotoxic activity against CCl4-induced hepatotoxicity in rats. Some compounds demonstrated a significant antihepatotoxic activity comparable to the standard drug Silymarin.

Full text of DOI:10.3109/14756366.2010.489899

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