Dendrimers of vaccines consisting of tumor-associated glycopeptide antigens and T cell epitope peptides

Article abstract of DOI:10.1055/s-0028-1088033

According to the principle of multiple antigen presentation (MAP), a di-lysyl lysine core was used for the synthesis of tetramers of a glycododecapeptide antigen from the tandem-repeat sequence of the tumor-associated mucin, MUC1, which carries a sialyl T_N-antigen saccharide side chain. The methodology was extended to the analogous construction of a tetrameric vaccine consisting of a T cell epitope from tetanus toxoid and the sialyl T_N-glycododecapeptide of MUC1. Georg Thieme Verlag Stuttgart.