A base labile protecting group for peptide synthesis: 2,2,-Bis(4'-nitrophenyl)ethan-1-oxycarbonyl urethanes

DOI: 10.1016/S0040-4020(01)81953-0

Source and publish data:

Tetrahedron p. 8001 - 8024 (1991)

Update date:2022-08-05

Topics:

Authors:

Ramage Ramage

Blake Blake

Florence

Gray Gray

Raphy Raphy

Roach Roach

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Article abstract of DOI:10.1016/S0040-4020(01)81953-0

A base labile urethane (Bnpeoc) group derived from 2,2,-bis(4'-nitrophenyl)ethan-1-ol has been developed as an amine protecting group. This protecting group may be cleaved using the reagents DBN, DBU, DBU/HOAc and piperidine. The preparations of N(α)-Bnpeoc amino acids and applications to peptide/glycopeptide synthesis are described.

Full text of DOI:10.1016/S0040-4020(01)81953-0

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Product name:Glycine, N-[N-[N-[[2,2-bis(4-nitrophenyl)ethoxy]carbonyl]-L-alanyl]-L-phenylalanyl]- , methyl ester

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