Application of the Benzyloxycarbonyloxymethyl Moiety to a Protective Group of 5-Fluoroacil. Selective Alkylation of Amide Nitrogen of the Uracil Ring

DOI: 10.1246/cl.1988.1381

Source and publish data:

Chemistry Letters p. 1381 - 1384 (1988)

Update date:2022-08-04

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Authors:

Nagase, Toshio

Seike, Kanzo

Shiraishi, Kazuto

Yamada, Yutaka

Ozaki, Shoichiro

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Article abstract of DOI:10.1246/cl.1988.1381

Selective alkylation of 5-fluorouracil using the benzoyloxycarbonyloxymethyl moiety as a protective group of amide nitrogen of the uracil ring is described.Protection, alkylation and deprotection were carried out in high yields.

Full text of DOI:10.1246/cl.1988.1381

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