Synthesis and in vitro opioid receptor functional antagonism of methyl-substituted analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3- hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3, 4-tetrahydro-3-isoquinolinecarboxamide (JDTic

Article abstract of DOI:10.1021/jm900756t

In previous structure-activity relationship (SAR) studies, (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1- piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3- isoquinolinecarboxamide (JDTic, 3) was identified as the first pote