Bioorganic and Medicinal Chemistry Letters p. 5162 - 5165 (2009)
Update date:2022-08-03
Topics:
Hiraiwa, Yukiko
Morinaka, Akihiro
Fukushima, Takayoshi
Kudo, Toshiaki
4-Butyl-3-methylphthalic acid was recognized as a metallo-β-lactamase inhibitor. The structure-activity relationship study of substituted phthalic acids afforded 3-phenylphthalic acid derivatives as potent IMP-1 inhibitors. On the other hand, 3-substituted with 4-hydroxyphenyl phthalic acid derivative displayed a potent combination effect with biapenem (BIPM) against Pseudomonas aeruginosa that produce IMP-1.
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