ENANTIOSELECTIVE TOTAL SYNTHESIS OF (+)-NEGAMYCIN

DOI: 10.1016/S0040-4039(00)86063-3

Source and publish data:

Tetrahedron Letters p. 2373 - 2376 (1988)

Update date:2022-08-04

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Authors:

Tanner, David

Somfai, Peter

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Article abstract of DOI:10.1016/S0040-4039(00)86063-3

An efficient enantioselective total synthesis of the antibiotic (+)-negamycin is described, the absolute stereochemistry deriving from (R)-(+)-malic acid and subsequent use of the Sharpless asymmetric epoxidation reaction.

Full text of DOI:10.1016/S0040-4039(00)86063-3

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