ENANTIOSELECTIVE TOTAL SYNTHESIS OF (+)-NEGAMYCIN

Article abstract of DOI:10.1016/S0040-4039(00)86063-3

An efficient enantioselective total synthesis of the antibiotic (+)-negamycin is described, the absolute stereochemistry deriving from (R)-(+)-malic acid and subsequent use of the Sharpless asymmetric epoxidation reaction.