SYNTHESIS OF HEPARIN FRAGMENTS: A METHYL α-PENTANOSIDE WITH HIGH AFFINITY FOR ANTITHROMBIN III

DOI: 10.1016/0008-6215(87)80268-9

Source and publish data:

Carbohydrate Research p. 67 - 76 (1987)

Update date:2022-08-05

Topics:

Authors:

Petitou, Maurice

Duchaussoy, Philippe

Lederman, Isidore

Choay, Jean

Jaquinet, Jean-Claude

et al. et al.

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Article abstract of DOI:10.1016/0008-6215(87)80268-9

The synthesis is described of the methyl α-glycoside of the pentasaccharide which represents the sequence in heparin responsible for binding and activation of the anticoagulant protein Antithrombin III.It was obtained in a yield much better than that of the previously synthesized pentasaccharide and exhibited the same biological properties.

Full text of DOI:10.1016/0008-6215(87)80268-9

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Product name:methyl (2-azido-2-deoxy-6-O-sulfonato-α-D-glucopyranosyl)-(1→4)-(β-D-glucopyranosyluronate)-(1→4)-(2-amino-2-deoxy-3,6-di-O-sulfonato-α-D-glucopyranosyl)-(1→4)-(2-O-sulfonato-α-L-idopyranosyluronate)-(1→4)-2-amino-2-deoxy-6-O-sulfonato-α-D-glucopyranoside sodium salt

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