Synthesis of 4-Substituted Prolines as Conformationally Constrained Amino Acid Analogues

DOI: 10.1021/jo00269a022

Source and publish data:

Journal of Organic Chemistry p. 1859 - 1866 (1989)

Update date:2022-08-04

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Authors:

Koskinen, Ari M. P.

Rapoport, Henry

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Article abstract of DOI:10.1021/jo00269a022

Anionic substitution of N-(9-(9-phenylfluorenyl))-protected glutamic acid esters proceeds without loss of optical integrity to give 4-substituted glutamic acid derivatives.The 4-methyl, propyl, cyanomethyl, and phenyl analogues have thus been prepared.Pri

Full text of DOI:10.1021/jo00269a022

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