Conjugate Addition of Grignard Reagents to Enones and Dienones

DOI: 10.1021/jo00271a014

Source and publish data:

Journal of Organic Chemistry p. 2317 - 2321 (1989)

Update date:2022-07-29

Topics:

Authors:

Modi, Sandeep P.

Gardner, John O.

Milowsky, Arnold

Wierzba, Mark

Forgione, Lisa

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00271a014

Grignard reaction with 16-dehydropregnenolone acetate, 1, results in 1,4-addition to the enone system.Introduction of even trace amounts of oxygen before the reaction has been fully quenched results in formation of 17α-hydroperoxides as well as the expect

Full text of DOI:10.1021/jo00271a014

Products guided by the article

Product name:3β-hydroxy-16α-phenylpregn-5-en-20-one

Cas No:119680-02-3

R&D Labs maybe for 119680-02-3

Suzhou Chiral Pharmaceuticals Co., Ltd.

Contact:86-0512-63197058

Address:Building A, No. 2358, Chang'an Road, Wujiang Science Park
Xiamen Huasing Chemicals Co.Ltd.

Contact:0086-592-6228397

Address:NO.24, Xinglin North 2nd Road,Jimei district
nanjing suru chemical co.ltd

Contact:+86-025-52406782

Address:8 Taizishan Rd., Yanjiang Industrial Development Area, Nanjing, Jiangsu, China.
Qingdao S. H. Huanyu Imp. & Exp. Co., Ltd.

Contact:86-532-88250866

Address:Room 615, World Trade Centre Building B, Hongkong Middle Roda 6#, Qingdao, Shandong, China
Shanghai AoBo Bio-Pharmaceutical Technology Co., Ltd.

Contact:+86-21-51320130-801, 816

Address:Room 601, No. 1011, Halei Road, Zhangjiang High-Tech Park, Pudong, Shanghai

Relevant to this article

Efficient, regioselective access to bicyclic imidazo[1,2-x]- heterocycles via gold- and base-promoted cyclization of 1-alkynylimidazoles

Doi:10.1021/jo902073m
(2009)
From serendipity to rational antituberculosis drug discovery of mefloquine-isoxazole carboxylic acid esters

Doi:10.1021/jm900340a
(2009)
SYNTHESIS OF 1H-PYRIDAZIN-4-ONE DERIVATIVES FROM ACETYLACETONE THROUGH ITS DIFLUOROBORYL CHELATE

Doi:10.1007/BF00962778
()
Stereoselective dehalogenation of (Z)-1-halo-1-alkenyldialkylborane with tributyltin hydride: The behavior of tributyltin hydride as a hydride donor

Doi:10.1016/S0040-4039(96)02324-6
(1997)
Model investigations of vanadium-protein interactions: Novel vanadium(III) and oxovanadium(IV) compounds with the diamidate ligand 1,2-bis(2-pyridinecarboxamide)benzene (H₂bpb)

Doi:10.1021/ic990837z
(2000)
Syntheses of morpholine-2,3-diones and 2-hydroxymorpholin-3-ones: Intermediates in the synthesis of aprepitant

Doi:10.1016/j.tetlet.2004.09.185
(2004)

Article Doi