SYNTHESIS OF KETOMETHYLENE DIPEPTIDES CONTAINING BASIC AMINO ACID ANALOGUES AT C-TERMINUS

DOI: 10.1016/S0040-4020(01)86018-X

Source and publish data:

Tetrahedron p. 5131 - 5138 (1988)

Update date:2022-08-04

Topics: Synthesis Chromatography Reactants Nucleophilic addition NMR (nuclear magnetic resonance) Spectroscopy C-terminus

Authors:

Garcia-Lopez, Maria Teresa

Gonzalez-Muniz, Rosario

Harto, Juan R.

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Article abstract of DOI:10.1016/S0040-4020(01)86018-X

The four ketomethylene dipeptides Pheψ(COCH2)(RS)Orn (6a)and Trpψ(COCH2))(RS)X X=(RS)Orn (6b), (RS)Arg (8b) and (RS)Lys (12b) have been synthesized by a route involving two successive principal reactions: a malonic ester alkylation with the corresponding

Full text of DOI:10.1016/S0040-4020(01)86018-X

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