881674-56-2 Usage
Chemical Properties
Light orange to Yellow to Green powder to crystal.
Uses
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde acts as a reagent in the synthetic preparation of novel pyrrole derivatives as potassium-competitive acid blocker (P-CAB).
Application
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is a potassium ion-competitive acid blocker used in therapy Acid-related diseases, gastric ulcer, duodenal ulcer, reflux esophagitis, etc.
Preparation
Synthesis of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde: Using pyrrole as raw material, after being protected by N-alkylation of triisopropylsilyl chloride, it is then reacted with Vilsmeier reagent to obtain 1H-Pyrrole-3-carbaldehyde, which is then purified by N-bromosuccinimide (NBS) bromination and 2-fluorophenylboronic acid for Suzuki coupling reaction to obtain crude 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde, which was purified with toluene. The total yield was 35.5%.
Check Digit Verification of cas no
The CAS Registry Mumber 881674-56-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,1,6,7 and 4 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 881674-56:
(8*8)+(7*8)+(6*1)+(5*6)+(4*7)+(3*4)+(2*5)+(1*6)=212
212 % 10 = 2
So 881674-56-2 is a valid CAS Registry Number.
881674-56-2Relevant articles and documents
Preparation method of vonoprazan fumarate intermediate
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Paragraph 0056-0066, (2021/06/21)
The invention provides a preparation method of a vonoprazan fumarate intermediate, and particularly provides a preparation method of a compound shown as a formula I. The preparation method comprises the following steps: reacting o-fluorobenzonitrile with
Preparation method 5 - (2 - fluorophenyl) - 1H - pyrrole -3 - formaldehyde
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Paragraph 0079-0100, (2021/10/20)
The invention provides a preparation method of 5 - (2 - fluorophenyl) - 1H - pyrrole -3 - formaldehyde, which comprises the following steps of A: 2 - chlorine -5 - (2 - fluorophenyl) - 1H - pyrrole -3 - carbonitrile in a solvent. In the base and palladium
Preparation method 5 - (2 - fluorophenyl) - 1H - pyrrole -3 - formaldehyde
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Paragraph 0072-0089, (2021/11/19)
The invention belongs to the technical field of pharmaceutical chemicals, and particularly relates to a preparation method of 5 - (2 - fluorophenyl) - 1H - pyrrole -3 - formaldehyde. The preparation method of 5 - (2 - fluorophenyl) - 1H - pyrrole -3 - for
