INTRAMOLECULAR METAL CATALYZED KHARASCH CYCLIZATION OF OLEFINIC α-HALO ESTERS AND ACIDS

Article abstract of DOI:10.1016/S0040-4020(01)86169-X

Functionalized carbocyclyc compounds are produced by intramolecular Kharasch radical cyclization reactions catalyzed by various transition metal complexes.Several unsaturated mono-α-haloesters and acids can be efficiently transformed to γ-halocarboxyl and γ-lactone carbocycles via exo closure of a 5-hexenyl type radical intermediate.The cyclization methodology is useful for synthesis of both fused and bridged carbocycles.