Journal of Medicinal Chemistry p. 1398 - 1401 (1989)
Update date:2022-08-03
Topics:
Balsamo
Broccali
Lapucci
Macchia
Macchia
Orlandini
Rossello
Some β-aminoxypropionyl penicillins (3) and cephalosporins (4 and 5), planned on the basis of the hypothesis that the (methyleneaminoxy)methyl group (>C = NOCH2) could be a 'bioisoster' of either aryls or other aromatic groups, were synthesized and assayed for their antimicrobial properties. Compounds 3-5, tested on Gram-positive and Gram-negative bacteria, both sensitive to enzyme inactivation and otherwise, exhibited an activity trend that was not substantially different from that of the corresponding phenylacetamido derivatives taken as terms of comparison.
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