Enzyme-catalyzed Asymmetric Hydrolysis of meso-Substrate. The Facile Synthesis of Both Enantiomers of cis-2,5-Disubstituted Tetrahydrofuran Derivatives

Article abstract of DOI:10.1246/cl.1988.1717

The enzyme-catalyzed asymmetric hydrolysis of the meso-diesters derived from cis-2,5-bis(hydroxymethyl)tetrahydrofuran in presence of PLE, PPL, and CCL afforded the optically active half-esters.The both enantiomers of cis-5-(hydroxymethyl)tetrahydrofuran-2-carboxylic acid with high optical purity were prepared from the half-esters.