Asymmetric Synthesis via Acetal Templates. 15. The Preparation of Enantiomerically Pure Mevinolin Analogs

DOI: 10.1016/S0040-4039(00)82107-3

Source and publish data:

Tetrahedron Letters p. 3757 - 3760 (1988)

Update date:2022-08-05

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Authors:

Johnson, William S.

Kelson, Andrew B.

Elliott, John D.

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Article abstract of DOI:10.1016/S0040-4039(00)82107-3

An efficient asymmetric synthesis of the hydroxylactone moiety of mevinolin 1 is described.The key step is the TiCl₄-catalyzed coupling reaction of acetals 3a and 3b derived from (R)-1,3-butanediol with 1,3-bis(trimethylsilyloxy)-1-methoxybuta-

Full text of DOI:10.1016/S0040-4039(00)82107-3

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