Tetrahydroquinoline derivatives as CRTH2 antagonists

DOI: 10.1016/j.bmcl.2009.10.094

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 6840 - 6844 (2009)

Update date:2022-08-05

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Authors:

Liu, Jiwen

Wang, Yingcai

Sun, Ying

Marshall, Derek

Miao, Shichang

Tonn, George

Anders, Penny

Tocker, Joel

Tang, H. Lucy

Medina, Julio

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Article abstract of DOI:10.1016/j.bmcl.2009.10.094

A series of tetrahydroquinoline-derived inhibitors of the CRTH2 receptor was discovered by a high throughput screen. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent and orally bioavailable CRTH2 an

Full text of DOI:10.1016/j.bmcl.2009.10.094

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