Hydroxy Group as a Regio- and Stereochemical Control Element for Sequential Metal-Catalyzed and Thermal Cyclizations

Article abstract of DOI:10.1021/jo00271a006

Stereocontrolled creation of fused ring systems from acyclic precursors in vokes the powerful directive effect of the hydroxy group in which regioselectivity of a metal-catalyzed reaction totally changes and diastereofacial selectivity of the thermal step shows an unusual dependance on dienophile.