Substituted benzothiophene or benzofuran derivatives as a novel class of bone morphogenetic protein-2 up-Regulators: Synthesis, structure-activity relationships, and preventive bone loss efficacies in senescence accelerated mice (SAMP6) and ovariectomized

Article abstract of DOI:10.1021/jm901685n

In this work, substituted benzothiophene and benzofuran compounds were found to be a new class of potential anabolic agents by enhancing BMP-2 expression. A series of benzothiophene and benzofuran derivatives have been synthesized, and their activities of