CAS No.72-19-5,L-Threonine Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	72-19-5
Name:	L-Threonine
Article Data:	238
Cas Database

Formula:	C₄H₉NO₃
Molecular Weight:	119.12
Synonyms:	Butanoic acid, 2-amino-3-hydroxy-, (R-(R,S))-;Thr;Threonine [USAN:INN];L-Threonin;(2S,3R)-2-azaniumyl-3-hydroxy-butanoate;Treonina [Spanish];(2R,3R)-2-amino-3-hydroxy-butanoic acid;Threonine, L-;(2S,3R)-2-Amino-3-hydroxybutyric acid;Valine,3-hydroxy-;L-alpha-Amino-beta-hydroxybutyric acid;(2S,3S)-2-azaniumyl-3-hydroxy-butanoate;(2S)-threonine;Threoninum [Latin];Threonine (VAN);L-2-Amino-3-hydroxybutyric acid;L-Threonine(Feed Grade);L-Thr-OH;L-Threonine Aji97;Threonine, L- (8CI);(2S,3R)-2-amino-3-hydroxy-butanoic acid;L-(-)-Threonine;Threonin;[R-(R,S)]-2-Amino-3-hydroxybutanoic acid;L-Threonine (9CI);Threonine (USP);
EINECS:	200-774-1
Density:	1.307 g/cm³
Melting Point:	256 °C (dec.)(lit.)
Boiling Point:	345.803 °C at 760 mmHg
Flash Point:	162.936 °C
Solubility:	90 g/L (20 °C) in water
Appearance:	White crystalline powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	24/25-37/39-26
PSA:	83.55000
LogP:	-0.52060

Related products

Synthetic route

: 111-26-2
hexan-1-amine

: (S)-2-(3,5-Dinitro-4-oxo-4H-pyridin-1-yl)-3-hydroxy-butyric acid

A: 72-19-5
L-threonine

B: 74197-48-1
1-hexyl-3,5-dinitro-4-pyridone

Conditions

Conditions	Yield
In pyridine Product distribution;	A 83.8% B n/a

...Expand

: 67-56-1
methanol

: 73731-37-0, 130674-54-3, 146306-75-4
Fmoc-Thr-OH

A: 72-19-5
L-threonine

B: 2812-27-3, 2812-28-4, 21148-57-2, 95539-41-6, 100157-57-1
N-methyl threonine

C: 2812-36-4, 2812-37-5, 138406-48-1
N,N-dimethyl-threonine

Conditions

Conditions	Yield
With hydrogen; acetic acid; palladium on activated charcoal for 48h; other (protected) amino acids; other alcohol;	A n/a B 40% C n/a

...Expand

: 72-19-5, 80-68-2, 144-98-9, 632-20-2, 2676-21-3, 7004-04-8, 24830-94-2, 28954-12-3, 36676-50-3
DL-threonine

A: 72-19-5
L-threonine

B: 72-19-5, 80-68-2, 144-98-9, 632-20-2, 2676-21-3, 7004-04-8, 24830-94-2, 28954-12-3, 36676-50-3
D-threonine

Conditions

Conditions	Yield
Yields of byproduct given;

: 75-07-0
acetaldehyde

: 56-40-6
glycine

: 72-19-5
L-threonine

Conditions

Conditions	Yield
With pyridoxal 5'-phosphate; L-threonine aldolase In phosphate buffer at 25℃; for 3h;

: antimycin B1

: 72-19-5
L-threonine

Conditions

Conditions	Yield
With hydrogenchloride; water at 110℃; for 20h;

: ucb K115

: 72-19-5
L-threonine

Conditions

Conditions	Yield
With ferrous(II) sulfate heptahydrate; cobalt(II) sulphate heptahydrate; N-succinyl L-amino acid desuccinylase from Burkholderia ambifaria AMMD; N-succinyll-amino acid β-hydroxylase from Burkholderia ambifaria AMMD; ascorbic acid In aq. phosphate buffer at 30℃; for 24h; Enzymatic reaction;

: 67-56-1
methanol

: 72-19-5
L-threonine

: 39994-75-7, 60538-15-0, 60538-18-3, 62076-66-8, 76419-75-5, 79617-27-9, 108724-12-5
L-threonine methyl ester hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 0℃; for 3.25h; Reflux;	100%

: 72-19-5
L-threonine

: 79-22-1
methyl chloroformate

: (2S,3R)-3-hydroxy-2-((methoxycarbonyl)amino)butanoic acid

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide; sodium carbonate In methanol; dichloromethane	98%
With sodium hydrogencarbonate In diethyl ether; water

: [Pd(acetylacetonato-O,O')((1R,2R)-(PPh2NH)2C6H10)](ClO4)

: 72-19-5
L-threonine

: [Pd(L-threoninate-κ-N,O)((1R,2R)-(PPh2NH)2C6H10)](ClO4)

Conditions

Conditions	Yield
In methanol byproducts: acetylacetone; to a soln. of complex in methanol was added amino acid, the mixt. was refluxed for 3 h, cooled; evapd. to dryness, treated with diethyl ether, the solid was filtered, washed with diethyl ether, air-dried;	85%

: 72-19-5
L-threonine

: 104-15-4
toluene-4-sulfonic acid

: 107-18-6
allyl alcohol

: 88224-11-7
L-Threonin-allylester-hydro-p-toluolsulfonat

Conditions

Conditions	Yield
In benzene Heating;	84%

...Expand

Raw Materials

56-87-1

Downstream Products

556-50-3

107-92-6

Total:324 Page 1 of 9 1 2 3 4 5 6 …9 Next>>

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Chemistry

Structure of L-Threonine (CAS NO.72-19-5):

IUPAC Name: (2S,3R)-2-amino-3-hydroxybutanoic acid
Empirical Formula: C₄H₉NO₃
Molecular Weight: 119.1192
EINECS: 200-774-1
Index of Refraction: 1.507
Molar Refractivity: 27.13 cm³
Molar Volume: 91.1 cm3
Polarizability: 10.75×10^-24cm³
Surface Tension: 60 dyne/cm
Density: 1.307 g/cm³
Flash Point: 162.9 °C
Enthalpy of Vaporization: 68.32 kJ/mol
Melting Point: 256 °C (dec.)(lit.)
Boiling Point: 345.8 °C at 760 mmHg
Vapour Pressure: 3.77E-06 mmHg at 25°C
Storage temp: Store at RT.
Water Solubility: 90 g/L (20 ºC)
Stability: Stable. Incompatible with strong oxidizing agents.
Physical Appearance: White crystalline powder
Product Categories: Miscellaneous Biochemicals;Amino Acid Derivatives;Threonine [Thr, T];Amino Acids and Derivatives;alpha-Amino Acids;Amino Acids;Biochemistry;Nutritional Supplements;L-Amino Acids;Amino Acids
Synonyms of L-Threonine (CAS NO.72-19-5): (S)-Threonine ; 2-Amino-3-hydroxybutanoic acid, (R-(R*,S*))- ; Butanoic acid, 2-amino-3-hydroxy-, (R-(R*,S*))- ; Threonin ; Threonine ; Threoninum ; Treonina
Canonical SMILES: CC(C(C(=O)O)N)O
Isomeric SMILES: C[C@H]([C@@H](C(=O)O)N)O
InChI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1
InChIKey: AYFVYJQAPQTCCC-GBXIJSLDSA-N

Uses

L-Threonine (CAS NO.72-19-5) is an essential amino acid, but not synthesized in humans.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD50	intraperitoneal	3098mg/kg (3098mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives of Biochemistry and Biophysics. Vol. 58, Pg. 253, 1955.

Safety Profile

Hazard Codes: Xi
Risk Statements: 36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 24/25-37/39-26
24/25: Avoid contact with skin and eyes
37/39: Wear suitable gloves and eye/face protection
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29225000

Specification

1. First Aid Measures of L-Threonine (CAS NO.72-19-5):
Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation: Remove from exposure to fresh air immediately. Get medical aid if cough or other symptoms appear.
Skin: Get medical aid if irritation develops or persists. Flush skin with plenty of soap and water.
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
2. Handling and Storage:
Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.