Identification and structure - Activity relationships of chromene-derived selective estrogen receptor modulators for treatment of postmenopausal symptoms

DOI: 10.1021/jm900146e

Source and publish data:

Journal of Medicinal Chemistry p. 7544 - 7569 (2009)

Update date:2022-09-26

Topics:

Authors:

Jain, Nareshkumar

Xu, Jiayi

Kanojia, Ramesh M.

Du, Fuyong

Guo, Jian-Zhong

Pacia, Emmanuel

Lai, Muh-Tsann

Musto, Amy

Allan, George

Reuman, Michael

Li, Xun Li, Xun

Hahn, DoWon

Cousineau, Martin

Peng, Sean

Ritchie, David

Russell, Ronald

Lundeen, Scott

Sui, Zhihua

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Article abstract of DOI:10.1021/jm900146e

As part of a program aimed at the development of selective estrogen receptor modulators (SERMs), novel chromene scaffolds, benzopyranobenzoxapanes, were discovered. Many compounds showed binding affinity as low as 1.6-200 nM, displayed antagonist behavior

Full text of DOI:10.1021/jm900146e

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