Titanium Tetrachloride Induced Fries Rearrangement: A New Route to Disubstituted 2'-Hydroxypropiophenones

DOI: 10.1055/s-1989-27134

Source and publish data:

Synthesis p. 25 - 28 (1989)

Update date:2022-09-26

Topics:

Authors:

Martin, Robert

Demerseman, Pierre

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1055/s-1989-27134

Fries rearrangement of some dialkylphenyl propionates with titanium tetrachloride proves to be a convenient route to hindered dialkyl 2'-hydroxypropiophenones.The sequential use of soft titanium tetrachloride to perform the Fries rearrangement followed by hard aluminum chloride to achieve the elimination of a protecting tert-butyl group allows the synthesis of some previously unknown 3',6'- and 5',6'-dialkyl-2-hydroxypropiophenones.

Full text of DOI:10.1055/s-1989-27134

Products guided by the article

Product name:m-thymyl propionate

Cas No:121194-58-9

R&D Labs maybe for 121194-58-9

Shanghai UCHEM Inc.

Contact:+86-21-56338808

Address:799 Dunhuang Road, Putuo
SPRING CHEMICAL INDUSTRY CO.,LTD

Contact:86-187-66672125

Address:linchi industry park.zouping
Ningbo J&S Botanics Inc.

Contact:86-574-26865651

Address:529 YuanBaoShan Road, Beilun District
SEA BRGIHT INDUSTRY CO.,LIMITED

Contact:0086 755 8622 3990

Address:Rm 17B3,GuangCaiXinTianDi Bldg,GuiMiao Rd,NanShan District,Shenzhen,China
Tianjin Anda North Industrial & Business Co.Ltd.

Contact:86-22-24999306

Address:No.11 Erwei Road,Dongli Development Area,Tianjin,China

Relevant to this article

Enantioselective rhodium-catalyzed [2 + 2 + 2] cycloadditions of terminal alkynes and alkenyl isocyanates: Mechanistic insights lead to a unified model that rationalizes product selectivity

Doi:10.1021/ja905065j
(2009)
Host-Guest complexation-triggered chiroptical change of poly(phenylacetylene)s bearing binaphthocrown ether moieties on the main chain

Doi:10.1002/pola.23881
(2010)
Doi:10.1021/ja00951a017
(1965)
tert-Amino effect in naphthalene proton sponges: a novel approach to benzo[h]quinoline and quino[7,8:7',8']quinoline derivatives

Doi:10.1016/j.mencom.2010.01.014
(2010)
Synthesis of 2,3-Bis(arylamino)benzofurans and 2,3-Bis(arylimino)-2,3- dihydrobenzofurans by a Lewis Acid Catalyzed Reaction of 2-Aryliminophenols with Aryl Isocyanides

Doi:10.1055/s-0029-1218609
(2010)
A green procedure for the synthesis of 1,8-dioxodecahydroacridine derivatives under microwave irradiation in aqueous media without catalyst

Doi:10.1002/jhet.322
(2010)

Article Doi