Bioorganic and Medicinal Chemistry Letters p. 1604 - 1609 (2010)
Update date:2022-07-30
Topics:
Wang, Jane
Limburg, David
Carter, Jeff
Mbalaviele, Gabriel
Gierse, James
Vazquez, Michael
Here we describe the SAR of a series of potent and selective mPGES-1 inhibitors based on an oxicam template. Compound 13j demonstrated low nanomolar mPGES-1 inhibition in an enzyme assay. In addition, it displayed PGE2 inhibition in a cell-based assay (0.42 μM) and had over 238-fold selectivity for mPGES-1 over COX-2 and over 200-fold selectivity for mPGES-1 over 6-keto PGF1α.
Shifang Taifeng New Flame Retardant Co., Ltd
Contact:02884721008
Address:tingjiang industrial park, hefeng town
Shandong Hongxiang Zinc Co., Ltd
Contact:086-0311-66187879
Address:DaWang developing zone
Shanghai Rainbow Chemistry Co., Ltd.
Contact:+86-21-64968086-5815/5812
Address:3rd floor, Building 7, 251 Faladi Road, Zhangjiang Hi-Tech Park, Pudong District, Shanghai, P.R. China
KangZhiYuan Pharmaceutical Company Limited
Contact:(Sabrina)86-20-85273232
Address:4th floor, building B, Dadi industry zone, Tangxia, Tianhe, Guangzhou, China
TAIXING BEST NEW MATERIALS CO., LTD
Contact:0523-87998158;
Address:No.18 Zhonggang Road，Taixing City ，Jiangsu , China
Doi:10.1002/chem.201600535
(2016)Doi:10.1016/S0040-4039(01)99415-8
()Doi:10.1016/j.tet.2010.01.096
(2010)Doi:10.1016/j.bmcl.2010.01.141
(2010)Doi:10.1016/j.bmcl.2010.03.084
(2010)Doi:10.1016/0040-4020(95)00703-B
(1995)
