Ketene Chemistry 2. A General Procedure for the Synthesis of 2-Alkoxycyclopropanecarboxylic Esters and Acids Starting from Aldehydes and Ketene

Article abstract of DOI:10.1055/s-1989-27165

Alkyl 3-alkoxy-4-bromocarboxylates are prepared by the Lewis acid-catalyzed reaction of α-bromoaldehyde acetals with ketene.Base-catalyzed cyclization of these intermediates affords 2-alkoxycyclopropanecarboxylic esters.