Y. Fukuda et al. / Tetrahedron Letters 43 (2002) 2047–2049
2049
In summary, we have developed a novel methodology
for the diastereoselective construction of a quaternary
carbon stereogenic center on the prochiral carbon via
1,4-asymmetric induction during the RCM. The cyclo-
hexene derivatives generated by this reaction would be
versatile and flexible chiral building blocks for the
synthesis of biologically significant natural products.
Investigations into a possible mechanism of asymmetric
induction and further optimization, extension and
application of the methodology are currently underway
in our laboratories.
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