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144-55-8

Basic Information
CAS No.: 144-55-8
Name: Sodium bicarbonate
Molecular Structure:
Molecular Structure of 144-55-8 (Sodium bicarbonate)
Formula: NaHCO3
Molecular Weight: 84.01
Synonyms: Carbonic acid, monosodium salt;Natriumhydrogenkarbonat;Meylon;Carbonic acid disodium salt;SodaSee;Monosodium hydrogen carbonate;Monosodium carbonate;monosodium salt ;; see the subdivided heading;Component of Col-Evac;Soda Mint;Sodium bicarbonate(1:1);Carbonic acid, disodium salt;Natriumbicarbonat, Natriumhydrogencarbonat;Sodium Bicarbonate food grade;
EINECS: 205-633-8
Density: 2.173 g/cm3
Melting Point: 50 °C, 323 K, 122 °F (decomposes)
Boiling Point: 333.6 °C at 760 mmHg
Flash Point: 169.8 °C
Solubility: in water: 69 g/L (0 °C), 96 g/l (20 °C), 165 g/l (60 °C), 236 g/L (100 °C)
Appearance: white powder or crystals
Hazard Symbols:
Risk Codes:
Safety: 24/25
Transport Information:
PSA: 60.36000
LogP: -1.11230
Synthetic route
420-04-2

CYANAMID

1310-73-2

sodium hydroxide

B

144-55-8

sodium hydrogencarbonate

Conditions
ConditionsYield
In methanol after N. A. Gol'dberg and V. G. Golov, Zh. Prikl. Khim., 35, 2106 (1962);A 98%
B 2%
124-38-9

carbon dioxide

7647-14-5

sodium chloride

144-55-8

sodium hydrogencarbonate

Conditions
ConditionsYield
With ammonium chloride In water Gluud-Loepmann process: sepn. of pptd. NaHCO3 and NH4Cl;; very pure product;;95%
With ammonia In ammonia byproducts: NH4Cl; process includes NH4Cl recovery: treatment with CO2 under pressure;;
With CaHPO4 In water heating CaHPO4 and NaCl in presence of H2O vapor to 700-900°C, treatment of the resulting Na-Ca phosphate in H2O with CO2, formation of NaHCO3 and CaHPO4;;

3-Benzyloxycarbonylamino-1-(2-propyl)-5-(2,2,2-trifluoroethyl)-1,5-benzodiazepine-2-one

A

3-Amino-1-(2-propyl)-5-(2,2,2-trifluoroethyl)-1,5-benzodiazepine-2-one

B

144-55-8

sodium hydrogencarbonate

Conditions
ConditionsYield
In hydrogen bromide; acetic acidA 88%
B n/a
108-77-0

1,3,5-trichloro-2,4,6-triazine

227626-61-1

(1-carbamoylmethyl-cyclohexylmethyl)-carbamic acid tert-butyl ester

A

227626-62-2

(1-cyanomethyl-cyclohexylmethyl)-carbamic acid tert-butyl ester

B

144-55-8

sodium hydrogencarbonate

Conditions
ConditionsYield
In ice-water; N,N-dimethyl-formamideA 80%
B n/a
124-38-9

carbon dioxide

A

141-53-7

sodium formate

B

144-55-8

sodium hydrogencarbonate

Conditions
ConditionsYield
With RuCl2((iPr2PCH2CH2)2NH); water; hydrogen; sodium hydroxide at 140℃; under 25858.1 Torr; for 4h; Temperature;A 71%
B 29%
With RuCl2((iPr2PCH2CH2)2NH); water; hydrogen; sodium hydroxide at 130℃; under 25858.1 Torr; for 4h;A 29.5%
B 70.5%
177485-96-0

5-[N-tert-butoxycarbonyl-N-[5-(trifluoromethanesulfonamido)pentan-1-yl]aminomethyl]-imidazo[1,2-a]pyridine

76-02-8

Trichloroacetyl chloride

A

177485-97-1

3-trichloroacetyl-5-[N-tert-butoxy-carbonyl-N-[5-(trifluoromethanesulfonamido)pentan-1-yl]aminomethyl]imidazo[1,2-a]pyridine

B

144-55-8

sodium hydrogencarbonate

Conditions
ConditionsYield
With dmap In chloroformA 58.2%
B n/a

dinatriumdecacarbonylwolframate

A

15444-65-2

triphenylphosphine tungsten pentacarbonyl

B

141-53-7

sodium formate

C

144-55-8

sodium hydrogencarbonate

D

497-19-8

sodium carbonate

Conditions
ConditionsYield
With carbon dioxide; triphenylphosphine In acetonitrile Irradiation (UV/VIS); (Ar or N2); UV irradn. (>420 nm) of soln. of W compd. and PPh3 with stirring at ca. 20°C for ca. 12 h under CO2 pressure, formed ppt. was sepd.; W(CO)5PPh3 was detected IR spect. in filtrate, not isolated; NaHCOO detected 1HNMR spect. in D2O soln. of ppt.; Na2CO3 and NaHCO3 detd. in aq. soln. of ppt. by titrn.;A 70-90
B 20%
C 18%
D 39%

Na(1+)*H(1+)*W2(CO)10(2-)=NaHW2(CO)10

A

15444-65-2

triphenylphosphine tungsten pentacarbonyl

16743-03-6, 38800-77-0, 68738-00-1

trans-triphenylphosphane tetracarbonyltungsten

C

141-53-7

sodium formate

D

144-55-8

sodium hydrogencarbonate

E

497-19-8

sodium carbonate

Conditions
ConditionsYield
With carbon dioxide; triphenylphosphine In acetonitrile Irradiation (UV/VIS); (Ar or N2); UV irradn. (>420 nm) of soln. of W compd. and PPh3 with stirring at ca. 20°C for ca. 12 h under CO2 pressure, formed ppt. was sepd.; W compds. were detected IR spect. in filtrate, not isolated; NaHCOO detected 1HNMR spect. in D2O soln. of ppt.; Na2CO3 and NaHCO3 detd. in aq. soln. of ppt. by titrn.;A n/a
B n/a
C 30%
D 29%
E 27%
124-38-9

carbon dioxide

201230-82-2

carbon monoxide

497-19-8

sodium carbonate

A

141-53-7

sodium formate

B

62-76-0

sodium oxalate

C

144-55-8

sodium hydrogencarbonate

Conditions
ConditionsYield
In neat (no solvent) High Pressure; 2 h at 380°C; cooling, dissolution in water, addn. of HClO4; HPLC;A 0%
B 0%
C 0.5%
179416-72-9

diphenylmethyl α-[4-[4-(4-benzyloxycarbonylamidinophenoxy)butyl]-2,3-dioxopiperazin-1-yl]-α-phenylacetate

A

α-[4-[4-(4-Amidinophenoxy)butyl]-2,3-dioxopiperazin-1yl]-α-phenylacetic acid

B

144-55-8

sodium hydrogencarbonate

Conditions
ConditionsYield
With hydrogenchloride; palladium-carbon In N,N-dimethyl-formamide
320601-66-9

4-(3-(2-(benzylsulfanyl)-1H-imidazol-4-yl)phenyl)-1-hexanoyl-3,4-dimethylpiperidine

144-55-8

sodium hydrogencarbonate

320601-41-0

4-(3-(2-(benzylsulfanyl)-1H-imidazol-4-yl)phenyl)-1-hexyl-3,4-dimethylpiperidine

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; ethyl acetate100%
542-90-5

ethyl isothiocyanate

144-55-8

sodium hydrogencarbonate

106-49-0

p-toluidine

S-Ethyl-N-(4-methylphenyl)isothiourea

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane100%
24424-99-5

di-tert-butyl dicarbonate

5382-17-2

piperidin-4-ol hydrochloride

144-55-8

sodium hydrogencarbonate

109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

Conditions
ConditionsYield
In 1,4-dioxane100%
In 1,4-dioxane100%
24424-99-5

di-tert-butyl dicarbonate

144-55-8

sodium hydrogencarbonate

156-87-6

propan-1-ol-3-amine

58885-58-8

N-tert-butoxycarbonyl-3-aminopropanol

Conditions
ConditionsYield
In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran100%
144-55-8

sodium hydrogencarbonate

346414-37-7

4-(3-methylbenzo[b]thiophen-5-yl)-piperidine

346414-38-8

N-chloro-4-(3-methylbenzo[b]thiophen-5-yl)-piperidine

Conditions
ConditionsYield
With N-chloro-succinimide In tetrahydrofuran; water100%
591-35-5

3,5-dichlorophenol

144-55-8

sodium hydrogencarbonate

18162-48-6

tert-butyldimethylsilyl chloride

126663-61-4

1-<(tert-butyldimethylsilyl)oxy>-3,5-dichlorobenzene

Conditions
ConditionsYield
With hydrogenchloride; N-ethyl-N,N-diisopropylamine; dmap In dichloromethane100%
With hydrogenchloride; N-ethyl-N,N-diisopropylamine; dmap In dichloromethane100%
144-55-8

sodium hydrogencarbonate

151272-88-7

(R)-5-(3-nitropyrid-2-ylamino)-3-(pyrrolidin-2-ylmethyl)-1H-indole

17341-93-4

2,2,2-Trichloroethyl chloroformate

160906-49-0

5-(3-Nitropyrid-2-ylamino)-3-(N-(2,2,2-trichloroethoxycarbonyl)pyrrolidin-2R-ylmethyl)-1H-indole

Conditions
ConditionsYield
With pyridine In 1,1-dichloroethane; dichloromethane100%
CHCl3:MeOH

CHCl3:MeOH

14982-15-1

3-benzyloxyestra-1,3,5(10)-trien-17β-ol

5407-04-5

3-(dimethylamino)propyl chloride hydrochloride

144-55-8

sodium hydrogencarbonate

3-Benzyloxy-17(3-N,N-dimethylaminopropoxy)estra-1,3,5(10)-triene

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide; mineral oil100%
582-33-2

3-aminobenzoic acid ethyl ester

190728-25-7

4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline

32315-10-9

bis(trichloromethyl) carbonate

144-55-8

sodium hydrogencarbonate

190727-08-3

N-(3-Ethoxycarbonylphenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea

Conditions
ConditionsYield
With triethylamine In toluene100%
190728-25-7

4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline

32315-10-9

bis(trichloromethyl) carbonate

144-55-8

sodium hydrogencarbonate

10272-07-8

3,5-Dimethoxyaniline

N-(3,5-Dimethoxyphenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea

Conditions
ConditionsYield
With triethylamine In toluene100%
3731-51-9

(2-aminomethylpyridine)

190728-25-7

4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline

32315-10-9

bis(trichloromethyl) carbonate

144-55-8

sodium hydrogencarbonate

N-(4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl)-N'-(pyridin-2-ylmethyl)urea

Conditions
ConditionsYield
With triethylamine In toluene100%
190728-25-7

4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline

32315-10-9

bis(trichloromethyl) carbonate

6299-67-8

2,3-dimethoxyaniline

144-55-8

sodium hydrogencarbonate

N-(2,3-Dimethoxyphenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea

Conditions
ConditionsYield
With triethylamine In toluene100%
224055-63-4

(+)-genipin

144-55-8

sodium hydrogencarbonate

69977-52-2

1-methoxygenipin

Conditions
ConditionsYield
trifluoroboron diethylether In methanol100%
81250-34-2

1,3-dipropyl-5,6-diaminouracil

2094-72-6

1-Adamantanecarbonyl chloride

144-55-8

sodium hydrogencarbonate

127946-26-3

1,3-dipropyl-8-(1-adamantyl)xanthine

Conditions
ConditionsYield
In pyridine100%
137035-08-6

(R)-(+)-2-(4-chlorophenyl)-3,4-dihydro-2H-1,4-benzothiazine

144-55-8

sodium hydrogencarbonate

79-04-9

chloroacetyl chloride

(R)-4-chloroacetyl-2-(4-chlorophenyl)-3,4-dihydro-2H-1,4-benzothiazine

Conditions
ConditionsYield
In ethyl acetate100%
144-55-8

sodium hydrogencarbonate

100422-09-1

(1H,1H-Perfluorooctyl)phenyliodonium Triflate

3145-69-5

N-(1H,1H-perfluorooctyl)aniline

Conditions
ConditionsYield
With aniline In dichloromethane100%
286371-46-8

4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylaniline

576-26-1

2.6-dimethylphenol

32315-10-9

bis(trichloromethyl) carbonate

144-55-8

sodium hydrogencarbonate

2,6-Dimethylphenyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate

Conditions
ConditionsYield
With triethylamine In methanol; dichloromethane; chloroform; toluene100%
286371-46-8

4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylaniline

32315-10-9

bis(trichloromethyl) carbonate

144-55-8

sodium hydrogencarbonate

111-27-3

hexan-1-ol

hexyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate

Conditions
ConditionsYield
With triethylamine In methanol; dichloromethane; chloroform; toluene100%
286371-46-8

4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylaniline

32315-10-9

bis(trichloromethyl) carbonate

60-12-8

2-phenylethanol

144-55-8

sodium hydrogencarbonate

phenethyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate

Conditions
ConditionsYield
With triethylamine In methanol; dichloromethane; chloroform; toluene100%
286371-46-8

4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylaniline

32315-10-9

bis(trichloromethyl) carbonate

530-91-6

1,2,3,4-tetrahydronaphthalen-2 ol

144-55-8

sodium hydrogencarbonate

1,2,3,4-Tetrahydro-2-naphthalenyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate

Conditions
ConditionsYield
With triethylamine In methanol; dichloromethane; chloroform; toluene100%
286371-46-8

4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylaniline

821-09-0

n-Pent-4-enyl alcohol

32315-10-9

bis(trichloromethyl) carbonate

144-55-8

sodium hydrogencarbonate

4-Pentenyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy] - 2,5-dimethylphenyl}carbamate

Conditions
ConditionsYield
With triethylamine In methanol; dichloromethane; chloroform; toluene100%
576-26-1

2.6-dimethylphenol

190728-25-7

4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline

32315-10-9

bis(trichloromethyl) carbonate

144-55-8

sodium hydrogencarbonate

2,6-Dimethylphenyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate

Conditions
ConditionsYield
With triethylamine In methanol; dichloromethane; chloroform; toluene100%
190728-25-7

4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline

821-09-0

n-Pent-4-enyl alcohol

32315-10-9

bis(trichloromethyl) carbonate

144-55-8

sodium hydrogencarbonate

4-Pentenyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate

Conditions
ConditionsYield
With triethylamine In methanol; dichloromethane; chloroform; toluene100%
323206-47-9

(2S)-2-((2,6-dichlorophenyl)carbonylamino)-5-((tert-butoxy)carbonylamino)valeric acid methyl ester

144-55-8

sodium hydrogencarbonate

39920-37-1

2,6-dichlorophenylisocyanate

(2S)-2-((2,6-dichlorophenyl)carbonylamino)-5-(((2,6-dichlorophenyl)amino)carbonylamino)valeric acid methyl ester

Conditions
ConditionsYield
With triethylamine; trifluoroacetic acid In dichloromethane100%

(3S)-3-acetylthio-1-(4-carbamoyl-1,3-thiazol-2-yl)pyrrolidine

144-55-8

sodium hydrogencarbonate

93711-81-0, 90776-59-3

(4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

p-nitrobenzyl (1R,5S,6S)-2-[(3S)-1-(4-carbamoyl-1,3-thiazol-2-yl)pyrrolidin-3-yl]thio-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate

Conditions
ConditionsYield
With hydrazinium monoacetate; N-ethyl-N,N-diisopropylamine In N-methyl-acetamide; ethyl acetate; acetonitrile100%
144-55-8

sodium hydrogencarbonate

282110-53-6

4-phenethyl-3-(carbobenzyloxy)oxazolidin-5-one

Conditions
ConditionsYield
With p-toluenesulfonic acid monohydrate; paraformaldehyde In toluene100%
With p-toluenesulfonic acid monohydrate; paraformaldehyde In toluene100%
209222-91-3

1-(pyrrolidin-1-ylcarbonylmethyl)-2-oxo-3-(N-tert-butoxycarbonyl)amino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine

144-55-8

sodium hydrogencarbonate

1-(pyrrolidin-1-ylcarbonylmethyl)-2-oxo-3-amino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine

Conditions
ConditionsYield
In HCl-dioxane; dichloromethane100%
37167-62-7

bromo-phenyl-acetic acid methyl ester

144-55-8

sodium hydrogencarbonate

122555-91-3

1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane

sodium tert-butyl 2,2',2''-(10-(2-methoxy-2-oxo-1-phenylethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate bromide

Conditions
ConditionsYield
In acetonitrile at 30℃;100%
100-26-5

Pyridine-2,5-dicarboxylic acid

uranyl acetate

144-55-8

sodium hydrogencarbonate

Na2(H2O)2UO2(pyridine-2,5-dicarboxylate)2

Conditions
ConditionsYield
at 80 - 190℃; for 84h; Sealed tube; High pressure;100%
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    Sodium bicarbonate

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    Classification: Carbonate Type: Sodium Bicarbonate CAS No.: 144-55-8 Other Names: soda bicarbonate MF: NaHCO3 EINECS No.: 2056-33-8 Place of Origin: China (Mainland) Grade Standard: Food Gr… Appearance:white crystal powder Storage:cool and d

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    Sodium bicarbonate

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Specification

Sodium bicarbonate, with the formula NaHCO3, has the IUPAC name of Sodium hydrogen carbonate. It is a white solid that is crystalline but often appears as a fine powder. It will melt at 50 °C which is soluble in water. It is stable at normal pressure and temperature. The substance should be stored at cool, dry, well-ventilated place. In addition, it should be protected from strong oxides and acids. Sodium bicarbonate is amphoteric which can react with acids and bases. With the CAS register number of 144-55-8, the substance also has the EINECS registry number 205-633-8. Sodium bicarbonate is a component of the mineral natron and is found dissolved in many mineral springs. The substance is an amphoteric compound. Aqueous solutions are mildly alkaline due to the formation of carbonic acid and hydroxide ion. Sodium bicarbonate reacts with bases such as sodium hydroxide to form carbonates. Sodium bicarbonate and an acid can react to give a salt and carbonic acid which readily decomposes to give carbon dioxide and water. Sodium bicarbonate will gradually decompose into sodium carbonate and carbon dioxide above 70 °C. The conversion is more fast at 200 °C.When you are using this chemical, please be cautious about it as the following:  please avoid contact with skin and eyes.

Physical properties about Sodium bicarbonate are:
 (1)ACD/LogP: -0.809; (2)ACD/LogD (pH 5.5): -1.98; (3)ACD/LogD (pH 7.4): -3.77; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 3 ; (9)#H bond donors: 2 ; (10)Polar Surface Area: 46.53 ?2 ; (11)Polarizability: 10-24cm3; (12)Flash Point: 169.8 °C; (13)Enthalpy of Vaporization: 63.37 kJ/mol; (14)Boiling Point: 333.6 °C at 760 mmHg; (15)Vapour Pressure: 2.58E-05 mmHg at 25°C

Preparation of Sodium bicarbonate:
Sodium bicarbonate is mainly prepared by the Solvay process, which is the reaction of calcium carbonate, sodium chloride, ammonia, and carbon dioxide in water. It may be obtained by the reaction of carbon dioxide with an aqueous solution of sodium hydroxide. The initial reaction produces sodium carbonate. Further addition of carbon dioxide produces sodium bicarbonate.
CO2 + 2 NaOH → Na2CO3 + H2O
Na2CO3 + CO2 + H2O → 2 NaHCO3

Uses of Sodium bicarbonate:
 The Sodium bicarbonate was used as a cleansing agent like soap. Sodium bicarbonate was sometimes used in cooking vegetables, to make them softer. As a leavening agent, Sodium bicarbonate is primarily used in cooking. Sodium bicarbonate can be used as a wash to remove any acidic impurities from a "crude" liquid, producing a purer sample. Sodium bicarbonate can be added as a simple solution for raising the pH balance of water. Sodium bicarbonate is used in an aqueous solution as an antacid. Sodium bicarbonate is sold as a cattle feed supplement, in particular as a buffering agent for the rumen. It may also be used in an oral form to treat chronic forms of metabolic acidosis such as chronic renal failure and renal tubular acidosis. Sodium bicarbonate may also be used in urinary alkalinization for the treatment of aspirin overdose and uric acid renal stones. It is used as the medicinal ingredient in gripe water for infants. It is used as well for treatment of hyperkalemia. Sodium bicarbonate can be used as an exfoliant. Small amounts of Sodium bicarbonate have been shown to be useful as a supplement for endurance athletes. Sodium bicarbonate can be used to extinguish small grease or electrical fires by being thrown over the fire. However, as it may cause the grease to splatter, it should not be applied to fires in deep fryers.

You can still convert the following datas into molecular structure:

(1)Canonical SMILES: C(=O)(O)[O-].[Na+]
(2)InChI: InChI=1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
(3)InChIKey: UIIMBOGNXHQVGW-UHFFFAOYSA-M

The toxicity data of Sodium bicarbonate is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
infant TDLo oral 1260mg/kg (1260mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
American Journal of Diseases of Children. Vol. 135, Pg. 965, 1981.
man TDLo oral 20mg/kg/5D-I (20mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING American Journal of Emergency Medicine. Vol. 12, Pg. 57, 1994.
mouse LD50 oral 3360mg/kg (3360mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 33(5), Pg. 30, 1989.
rat LC inhalation > 900mg/m3 (900mg/m3)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 33(5), Pg. 30, 1989.
rat LD50 oral 4220mg/kg (4220mg/kg)   Toxicology and Applied Pharmacology. Vol. 6, Pg. 726, 1964.

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