Electrophilically activated nitroalkanes in reaction with aliphatic diamines en route to imidazolines

DOI: 10.1039/c9ra08630g

Source and publish data:

RSC Advances p. 39458 - 39465 (2019)

Update date:2022-07-29

Topics: Nitroalkanes Imidazolines

Authors:

Aksenov, Alexander V.

Aksenov, Nicolai A.

Arutiunov, Nikolai A.

Malyuga, Vladimir V.

Ovcharov, Sergey N.

Rubin, Michael

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Article abstract of DOI:10.1039/c9ra08630g

A novel synthetic methodology for the assembly of imidazolines via an unusual reaction between nitroalkanes and aliphatic 1,2-diamines in the presence of phosphorous acid is described. In contrast to the related highly efficient preparation of benzimidazoles from aromatic amines, this process represents a major synthetic challenge and for a long time was elusive. Analysis of the method limitations is provided.

Full text of DOI:10.1039/c9ra08630g

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