UNIVERSAL METHOD FOR THE FUNCTIONALIZATION
135
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(0.01 mol) and 0.01 g (0.002 mol) of Pd(PPh3)4 were
added to a stirred solution of organozinc compound at
20
°
С in one portion. After an exothermic reaction
3. Allen, K.N. and Abeles, R.N., Biochemistry, 1989,
completed, the mixture was stirred for 18 h at 20
°
С,
vol. 28, pp. 135–148.
and 30 mL of a saturated solution of ammonium chloꢀ
ride was added. The organic layer was separated, and
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the aqueous layer was extracted with ether (4 20 mL).
×
The combined organic extracts were washed with
20 mL of a saturated solution of ammonium chloride,
dried with sodium sulfate, and concentrated in a vacꢀ
uum. The residue was diluted with 30 mL of hexane,
catalyst decomposition products were separated by filꢀ
tration, and the filtrate was concentrated in a vacuum.
The residue was passed through a thin layer of silica gel
in a hexane–ethyl acetate (2 : 1) solution, and the
solution was concentrated. Adducts 2–7 were isolated
by column chromatography on silica gel with hexane–
ethyl acetate (2 : 1) as an eluent.
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DOKLADY CHEMISTRY Vol. 432
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2010