CYCLOAROMATIZATION OF α-OXOKETENE DITHIOACETALS WITH LITHIOACETONITRILE: A FACILE ROUTE FOR 4-SUBSTITUTED AND 4,5-ANNELATED PYRIDINES

DOI: 10.1016/S0040-4039(00)82416-8

Source and publish data:

Tetrahedron Letters p. 6633 - 6636 (1988)

Update date:2022-09-26

Topics:

Authors:

Gupta, Arun K.

Ila, Hiriyakkanavar

Junjappa, Hiriyakkanavar

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Article abstract of DOI:10.1016/S0040-4039(00)82416-8

A new general method for the synthesis of 4-substituted and 4,5-annelated pyridines has been developed by 1,2-addition of lithioacetonitrile to α-oxoketene dithioacetals followed by cycloaromatization of resulting carbinolacetals in the presence of phosphoric acid with concomitant 1,3-methylthio shift.

Full text of DOI:10.1016/S0040-4039(00)82416-8

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