
Tetrahedron Letters p. 2509 - 2512 (1989)
Update date:2022-07-29
Topics:
Macor, John E.
Newman, Michael E.
Ryan, Kevin
A two step synthesis of 2-vinyl indoles is described.Reaction of the anions of 2-methylindole-3-carboxylates (1) and (5) with ketones and aldehydes leads directly to 2-vinylindole-3-carboxylic acids (3) and esters (7), respectively.Decarboxylation of the acids (3) yields the desired 2-vinylindoles (4).
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