Mendeleev Communications p. 111 - 112 (2010)
Update date:2022-07-30
Topics:
Ivachtchenko, Alexandre V.
Yamanushkin, Pavel M.
Mitkin, Oleg D.
Kiselev, Oleg I.
Treatment of indomethacin with N-bromosuccinimide in AcOH results in bromination in aromatic positions 4 and 6, while the use of tetrachloromethane allows ultimate bromination at the C(2) Me group of the indole moiety to proceed.
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