Enantiospecific synthesis of [(2'S, 3'S)-bis(hydroxymethyl)azetidin-1-yl]pyrimidine nucleosides as potential antiviral agents

Article abstract of DOI:10.1016/S0040-4020(01)89342-X

The enantiospecific synthesis of [(2'S, 3'S)-bis(hydroxymethyl)azatidin-1-yl]pyrimidine nucleotides 22, 25, and 27 was achieved via construction of the base on the 1-aminoacetidine 18 prepared from (+)-diethyl-L-tartrate, and they are the first members of