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7491-74-9

Basic Information
CAS No.: 7491-74-9
Name: Piracetam
Molecular Structure:
Molecular Structure of 7491-74-9 (Piracetam)
Formula: C6H10N2O2
Molecular Weight: 142.18
Synonyms: Myocalm;Neuracetam;Nootobril;Nootobryl;Nootron;Nootrop;Nootropil;Nootropyl;Normabrain;Norzetam;(2-Oxopyrrolidino)acetamide;2-(2-Oxopyrrolidin-1-yl)acetamide;2-Ketopyrrolidine-1-acetamide;2-Oxo-1-pyrrolidineacetamide;2-Oxo-1-pyrrolidinylacetamide;2-Pyrrolidinoneacetamide;2-Pyrrolidoneacetamide;Avigilen;Axonyl;Cerebroforte;Cl 781;Encetrop;Euvifor;Gabacet;Genogris;Geram;
EINECS: 231-312-7
Density: 1.239 g/cm3
Melting Point: 151-152 °C
Boiling Point: 408.3 °C at 760 mmHg
Flash Point: 200.8 °C
Solubility:
Appearance:
Hazard Symbols: IrritantXi
Risk Codes: 36/37/38
Safety: 26-37/39
Transport Information:
PSA: 63.40000
LogP: -0.26770
Downstream Products
117947-07-6
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Chemistry

Molecular structure of Piracetam (CAS NO.7491-74-9) is:

Product Name: Piracetam
CAS Registry Number: 7491-74-9
IUPAC Name: 2-(2-oxopyrrolidin-1-yl)acetamide
Molecular Weight: 142.1558 [g/mol]
Molecular Formula: C6H10N2O2 
EINECS: 231-312-7
Melting Point: 151-152 °C
Surface Tension: 51.4 dyne/cm
Density: 1.239 g/cm3
Flash Point: 200.8 °C
Enthalpy of Vaporization: 66.03 kJ/mol
Boiling Point: 408.3 °C at 760 mmHg
Vapour Pressure: 7.06E-07 mmHg at 25°C
Product Categories: Miscellaneous;API's

History

In 1964 , Piracetam (CAS NO.7491-74-9) was first synthesized by scientists at the Belgian pharmaceutical company UCB led by Dr Corneliu E. Giurgea. The drug was the first of the so-called nootropics ("smart drugs" or "cognitive enhancers"); that is, substances can increase brain activity, mental performance, and vigilance. The term nootropic was coined by Giurgea. Nootropil was launched clinically by UCB in the early 1970s and remains an important product of that company in Europe.

Uses

 Piracetam (CAS NO.7491-74-9) is a drug which may enhance cognition and memory, may slow brain aging, may increase oxygen and blood flow to the brain,may improve Alzheimer's, may aid stroke recovery,  Down's syndrome, dementia, and dyslexia, among other diseases and conditions. Piracetam may be classified as a psychoactive stimulant.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 10gm/kg (10000mg/kg)   Russian Pharmacology and Toxicology Vol. 47, Pg. 205, 1984.
mammal (species unspecified) LD50 unreported > 10gm/kg (10000mg/kg)   Russian Pharmacology and Toxicology Vol. 44, Pg. 22, 1981.
mouse LD50 intraperitoneal > 10gm/kg (10000mg/kg)   Pharmaceutical Chemistry Journal Vol. 23, Pg. 795, 1989.
mouse LD50 intravenous 9200mg/kg (9200mg/kg)   Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 18, Pg. 465, 1983.
mouse LD50 oral 2gm/kg (2000mg/kg)   Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(4), Pg. 32, 1990.
mouse LD50 subcutaneous > 12gm/kg (12000mg/kg)   Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 11(8), Pg. 132, 1977.
rat LDLo oral 5600mg/kg (5600mg/kg)   Farmaco, Edizione Pratica. Vol. 32, Pg. 47, 1977.

Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS: UX9660500

Specification

 Piracetam , its cas register number is 7491-74-9. It also can be called 1-Acetamido-2-pyrrolidinone ; 2-Ketopyrrolidine-1-ylacetamide ; 2-Oxo-1-pyrrolidineacetamide ; 2-Oxo-pyrrolidin-1-ylacetamide ; 2-Oxo-pyrrolidine acetamide ; 1-Pyrrolidineacetamide, 2-oxo- .It is very soluble in water.

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