Pyridonecarboxylic acids as antibacterial agents. VI. Synthesis and structure-activity relationship of 7-(alkyl, cycloalkyl, and vinyl)-1-cyclopropyl-6-fluoro-4-quinolone-3-carboxylic acids

DOI: 10.1248/cpb.42.2049

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2049 - 2054 (1994)

Update date:2022-07-31

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Authors:

Todo Todo

Takagi Takagi

Iino Iino

Fukuoka Fukuoka

Ikeda Ikeda

Tanaka Tanaka

Saikawa Saikawa

Narita Narita

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Article abstract of DOI:10.1248/cpb.42.2049

The title compounds (1a-i) have been synthesized starting with ethyl 1-cyclopropyl-6,7-difluoro-4-quinolone-3-carboxylate (2). The 7-cyclopropyl and 7-vinyl derivatives (1e and 1i) exhibited potent in vitro antibacterial activities against both gram-posit

Full text of DOI:10.1248/cpb.42.2049

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Product name:ethyl 1-cyclopropyl-7-diphenylmethoxycarbonylmethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

Cas No:123161-30-8

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