Pyridonecarboxylic acids as antibacterial agents. VI. Synthesis and structure-activity relationship of 7-(alkyl, cycloalkyl, and vinyl)-1-cyclopropyl-6-fluoro-4-quinolone-3-carboxylic acids

DOI: 10.1248/cpb.42.2049

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2049 - 2054 (1994)

Update date:2022-07-31

Topics:

Authors:

Todo Todo

Takagi Takagi

Iino Iino

Fukuoka Fukuoka

Ikeda Ikeda

Tanaka Tanaka

Saikawa Saikawa

Narita Narita

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.42.2049

The title compounds (1a-i) have been synthesized starting with ethyl 1-cyclopropyl-6,7-difluoro-4-quinolone-3-carboxylate (2). The 7-cyclopropyl and 7-vinyl derivatives (1e and 1i) exhibited potent in vitro antibacterial activities against both gram-posit

Full text of DOI:10.1248/cpb.42.2049

NII-Electronic Library Service

Products guided by the article

Product name:ethyl 1-cyclopropyl-7-diphenylmethoxycarbonylmethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

Cas No:123161-30-8

R&D Labs maybe for 123161-30-8

Hawks Chemical

Contact:+44 (0)161 367 9441

Address:
Hebei Kangtai Pharmaceutical Co.,Ltd

Contact:+86-0317-3512963

Address:Wugang Road,Mengcun of Cangzhou City,Hebei Province ,China
Huaian Double Win Chemicals Co.,Ltd.

Contact:+86-13511538872

Address:Blk 43,Greenland Century Town,Huaian District, Huaian City,Jiangsu Province,China
SHANDONG ZHANHUA YONGHAO PHARMACEUTICAL TECH.CO.,LTD

Contact:+86-576-88685096

Address:GENGJU VILLAGE NORTH ONE KILOMETER,ZHANHUA DISTRICT,BINZHOU CITY,SHANDONG PROVINCE,CHINA.
LINAN HAIHUA CHEMICAL CO LTD

Contact:86-571-61063068

Address:LINAN

Relevant to this article

PyDipSi: A general and easily modifiable/traceless Si-tethered directing group for C-H acyloxylation of arenes

Doi:10.1021/ja1033167
(2010)
5-HYDROXY-7,8,2',4'-TETRAMETHOXYFLAVONE FROM LIMNOPHILA RUGOSA

Doi:10.1016/S0031-9422(00)97850-6
(1989)
An efficient one-pot and solvent-free synthesis of chromeno[2,3-d] pyrimidine derivatives: Microwave assisted reaction

Doi:10.3987/COM-10-11929
(2010)
Chirality-induced liquid crystalline properties of seven-ring trimeric mesogens incorporating dual chiral centers

Doi:10.1080/15421400902841353
(2009)
Synthesis, characterization, and applications of novel di-2-pyridyl imine ligands

Doi:10.1016/j.inoche.2009.10.013
(2010)
Selective deprotection of phenolic polysulfonates

Doi:10.1080/17415990903295694
(2010)

Article Doi