Synthesis and evaluation of new 2',3'-dideoxynucleoside analogs as potential anti-AIDS and anti-herpes drugs

DOI: 10.1016/0223-5234(92)90102-7

Source and publish data:

European Journal of Medicinal Chemistry p. 141 - 148 (1992)

Update date:2022-08-05

Topics:

Authors:

Faraj Faraj

Maillard

Lemaitre

Letellier

Frappier

Florent Florent

Grierson

Monneret

Zerial Zerial

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0223-5234(92)90102-7

Based on the known structure-activity relationships for the active anti-HIV, a series of 3'-deoxy-3'-N-functionalized thymidine analogs has been synthesized from thymidine. Evaluation for inhibitory activity against human immunodeficiency virus (HIV) replication in CEM cells and against herpes simplex virus in MRC-5 cells is reported.

Full text of DOI:10.1016/0223-5234(92)90102-7

Products guided by the article

Product name:Thymidine,3'-(cyanoamino)-3'-deoxy- (9CI)

Cas No:123533-07-3

R&D Labs maybe for 123533-07-3

Shanghai Balmxy Pharmaceutical Co., Ltd

Contact:0086-21-24206007

Address:Room 402, 15#, No. 909 wangyue Road, shanghai, P. R. China
Beijing Century Richap Chemistry Co.,Ltd

Contact:+86- 010-64455497

Address:Guannan County, Lianyungang City, Jiangsu Province, China
NINGBO YINZHOU PRECISE COLOR CO.,LTD.

Contact:86-574-88139809 86-574-83033159

Address:Qiming Road,Yinzhou,Ningbo,China
Penglai Qianwei Chemical Co., Ltd.

Contact:86-535-3357802

Address:Shahelu (north), Penglai, Shandong, China
Chongqing maohuan Chemicals Co., Ltd

website:http://www.bschem.com

Contact:+86 13996103726

Address:Chongqing Nan'an District Tu Town

Relevant to this article

Voltage-responsive vesicles based on orthogonal assembly of two homopolymers

Doi:10.1021/ja1027502
(2010)
Convergent synthesis of a steroidal antiestrogen-mitomycin C hybrid using "click" chemistry

Doi:10.1039/c2ob25902h
(2012)
Rapid Continous Peptide Synthesis via FMOC Amino Acid Chloride Coupling and 4-(Aminomethyl)piperidine Deblocking

Doi:10.1021/jo00289a056
(1990)
A novel, air-stable phosphine ligand for the palladium-catalyzed suzuki-miyaura cross-coupling reaction of chloro arenes

Doi:10.1021/jo100643j
(2010)
Intramolecular diamination and alkoxyamination of alkenes with N-sulfonyl ureas employing N-iodosuccinimide

Doi:10.1016/j.tet.2010.03.082
(2010)
Erratum: Chiral bisguanidine-catalyzed inverse-electron-demand hetero-diels-alder reaction of chalcones with azlactones (Journal of the American Chemical Society (2010) 132 (10650-10651))

Doi:10.1021/ja205501q
(2011)

Article Doi