Synthesis and evaluation of new 2',3'-dideoxynucleoside analogs as potential anti-AIDS and anti-herpes drugs

DOI: 10.1016/0223-5234(92)90102-7

Source and publish data:

European Journal of Medicinal Chemistry p. 141 - 148 (1992)

Update date:2022-08-05

Topics:

Authors:

Faraj Faraj

Maillard

Lemaitre

Letellier

Frappier

Florent Florent

Grierson

Monneret

Zerial Zerial

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Article abstract of DOI:10.1016/0223-5234(92)90102-7

Based on the known structure-activity relationships for the active anti-HIV, a series of 3'-deoxy-3'-N-functionalized thymidine analogs has been synthesized from thymidine. Evaluation for inhibitory activity against human immunodeficiency virus (HIV) replication in CEM cells and against herpes simplex virus in MRC-5 cells is reported.

Full text of DOI:10.1016/0223-5234(92)90102-7

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