Carbohydrate Research p. 93 - 107 (1993)
Update date:2022-08-03
Topics:
Kosma
Strobl
Marz
Kusumoto
Fukase
Brade
Brade
Sodium (allyl 3-deoxy-α-D-lyxo-2-heptulopyranosid)onate (6), allyl 3-deoxy-β- and -α-D-manno-2-octulopyranoside, sodium (allyl 3-deoxy-β-L-gulo-2-octulopyranosid)onate, sodium (allyl α-D-glycero-D-talo-2-octulopyranosid)onate, sodium (allyl α-D-glycero-D-galacto-2-octulopyranosidonate, ammonium (allyl 3-deoxy-4-O- and -5-O-phosphono-α-D-manno-2-octulopyranosid)onate, and ammonium (allyl 3-deoxy-4-O- and -5-O-phosphono-β-D-manno-2-octulopyranosid)onate were prepared and copolymerized with acrylamide to give multivalent haptens, which were used in immune inhibition assays. The monoclonal antibody A 20, directed against α-pyranoside Kdo residues, did not react with these compounds, except with heptulosonic acid derivative 6, thus proving that the terminal hydroxymethyl group of Kdo is not required for binding. Sodium (allyl 3-deoxy-α-D-(yxo-2-heptulopyranosid)onate (6), allyl 3-deoxy-β- and -α-D-manno-2-octulopyranoside, sodium (allyl 3-deoxy-β-L-gulo-2-octulopyranosid)onate, sodium (allyl α-D-glycero-D-talo-2-octulopyranosid)onate, sodium (allyl α-D-glycero-D-galacto-2-octolopyranosidonate, ammonium (allyl 3-deoxy-4-O- and -5-O-phosphono-α-D-manno-2-octulopyranosid)onate, and ammonium (allyl 3-deoxy-4-O- and -5-O-phosphono-β-D-manno-2-octulopyranosid)onate were prepared and copolymerized with acrylamide to give multivalent haptens, which were used in immune inhibition assays. The monoclonal antibody A 20, directed against α-pyranoside Kdo residues, did not react with these compounds, except with heptulosonic acid derivative 6, thus proving that the terminal hydroxymethyl group of Kdo is not required for binding.
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