Stereoselective synthesis of HR 780 a new highly potent HMG-CoA reductase inhibitor

DOI: 10.1016/0040-4039(90)80121-2

Source and publish data:

Tetrahedron Letters p. 2545 - 2548 (1990)

Update date:2022-09-26

Topics:

Authors:

Wess Wess

Kesseler

Baader Baader

Bartmann

Beck Beck

Bergmann

Jendralla

Bock Bock

Holzstein

Kleine Kleine

Schnierer

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Article abstract of DOI:10.1016/0040-4039(90)80121-2

HR 780 (1) a new HMG-CoA reductase inhibitor has been synthesized stereoselectively starting from L-malic acid. Wittig olefination employing phosphonium halides, phosphonates and phosphane oxides have been investigated.

Full text of DOI:10.1016/0040-4039(90)80121-2

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Product name:tert-butyl 2-((4R,6S)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

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