Stereoselective synthesis of HR 780 a new highly potent HMG-CoA reductase inhibitor

DOI: 10.1016/0040-4039(90)80121-2

Source and publish data:

Tetrahedron Letters p. 2545 - 2548 (1990)

Update date:2022-09-26

Topics:

Authors:

Wess Wess

Kesseler

Baader Baader

Bartmann

Beck Beck

Bergmann

Jendralla

Bock Bock

Holzstein

Kleine Kleine

Schnierer

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(90)80121-2

HR 780 (1) a new HMG-CoA reductase inhibitor has been synthesized stereoselectively starting from L-malic acid. Wittig olefination employing phosphonium halides, phosphonates and phosphane oxides have been investigated.

Full text of DOI:10.1016/0040-4039(90)80121-2

Products guided by the article

Product name:tert-butyl 2-((4R,6S)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

Cas No:124655-08-9

R&D Labs maybe for 124655-08-9

Ji'nan Orgachem Pharmaceutical Co.,Ltd

Contact:+86-531-82687810

Address:Jinan
Zhuhai Rundu Pharmaceutical co.,Ltd

Contact:+86-756-7630755

Address:No.6,North Airport Road,Sanzao Town,Jinwan District
Kono Chem Co.,Ltd

website:http://www.konochem.com

Contact:86-29-86107037

Address:No.170 West Avenue,Xi’an 710082,China
Shanghai Dynamic Industrial Co.,Ltd.

website:http://www.shdynamic.com

Contact:86-021 3392 6680

Address:Room 805 Information Tower, No.1403 Minsheng Road, Pudong New Area, Shanghai 200135, P. R. China
Hangzhou Kai Peng Biotechnology Co., Ltd.

Contact:86-571-89939007

Address:NO. 499, Wensan West Road, Xihu District, Hangzhou, 310012, China

Relevant to this article

Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors

Doi:10.1016/j.bmc.2010.06.068
(2010)
Thermally stable nonlinear optical polymers based on polyimides substituted with chromophores containing julolidine moiety

Doi:10.1080/15421400802329590
(2008)
Ruthenium-Catalyzed Direct Transformation of Alkenyl Oximes to 5-Cyanated Isoxazolines: A Cascade Approach Based on Non-Stabilized Radical Intermediate

Doi:10.1002/ejoc.201701651
(2018)
On the reactivity of alkylthio bridged 44 CVE triangular platinum clusters: Reactions with bidentate phosphine ligands

Doi:10.1002/zaac.200800037
(2008)
Synthese et thermolyse eclair d'esters α-tributylstanniques

Doi:10.1016/0022-328X(87)80020-7
(1987)
Construction of the 5,10b-phenanthridine skeleton using [3+2]-cycloaddition of a non-stabilized azomethine ylide: Total synthesis of (±)-maritidine and (±)-crinine alkaloids

Doi:10.1002/ejoc.201001263
(2011)

Article Doi