CAS No.50-65-7,Niclosamide Suppliers

Products Categories

Pharmaceutical (168)
Others (44)
Organic Chemicals (34)
Agrochemicals (14)
Materials (6)
Reagent (4)
Catalyst and Auxiliary (4)
(2)
Plant Extract (2)

Basic Information

Molecular Structure:
CAS No.:	50-65-7
Name:	Niclosamide
Article Data:	24

Formula:	C₁₃H₈Cl₂N₂O₄
Molecular Weight:	327.124
Synonyms:	Fenasal;Vermitid;2,5-Dichlor-4-nitro-salizylsaeureanilid [German];Chemagro 2353;N-(2-Chloro-4-nitrophenyl)-5-chlorosalicylamide;Nitrophenyl chlorsalicylamide;Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-;HL 2447;Salicylanilide, 2,5-dichloro-4-nitro-, compd. with 2-aminoethanol (1:1);2, 5-Dichlor-4-nitro-salizylsaeureanilid;Mansonil;Benzamide, 5-chloro-N- (2-chloro-4-nitrophenyl)-2-hydroxy-;Lintex;Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-, compd with 2-aminoethanol (1:1);Vermitin;5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide;Prestwick_354;Phenasal;2,5-Dichloro-4-nitrosalicylanilide;5,2-Dichloro-4-nitrosalicylanilide, ethanolamine salt;Bayer 2353;Phenasal ethanolamine salt;5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide compd with 2-aminoethanol;Niclosamide [BSI:ISO];2, 5-Dichloro-4-nitrosalicylanilide;Sulqui;Niclosamide-(2-hydroxyethyl)ammonium;WR 46234;Radeverm;SR 73;B 2353;2,5-Dichloro-4-nitrosalicyloylanilide ethanolamine salt;Benzamide,5-chloro-N-(2-chloro-4- nitrophenyl)-2-hydroxy-;Niclocide (TN);1420-04-8;Helmiantin;
EINECS:	200-056-8
Density:	1.616 g/cm³
Melting Point:	225-230oC
Boiling Point:	413.905 °C at 760 mmHg
Flash Point:	204.122 °C
Solubility:	13.32mg/L(25 oC)
Appearance:	white to yellowish odourless crystalline powder
Risk Codes:	50
Safety:	29
Transport Information:	UN 3077 9/PG 3
PSA:	95.15000
LogP:	4.45570

Synthetic route

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 121-87-9
2-Chloro-4-nitroaniline

: 50-65-7
Niclosamide

Conditions

Conditions	Yield
With phosphorus trichloride In chlorobenzene at 135℃; for 3h; Concentration; Solvent;	68.7%
With thionyl chloride In 5,5-dimethyl-1,3-cyclohexadiene at 78℃; for 6.1h; Temperature; Reflux;
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;
With phosphorus trichloride In 5,5-dimethyl-1,3-cyclohexadiene for 4h; Reflux;

: 6626-92-2
5-chloro-N-(2-chlorophenyl)-2-hydroxybenzamide

: 50-65-7
Niclosamide

Conditions

Conditions	Yield
With 3-(ethoxycarbonyl)-1-(5-methyl-5-(nitrosooxy)hexyl)pyridin-1-ium bis(trifluoromethanesulfonyl)imide at 20℃; for 5h; Ionic liquid;	48%

: niclosamide-2-O-glucuronide

: 50-65-7
Niclosamide

Conditions

Conditions	Yield
With β-glucuronidase for 0.333333h;

: 15216-81-6
5-chloro-2-hydroxybenzoyl chloride

: 121-87-9
2-Chloro-4-nitroaniline

: 50-65-7
Niclosamide

Conditions

Conditions	Yield
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; dichloromethane
In dichloromethane at 25℃; Inert atmosphere;

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 50-65-7
Niclosamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 12 h / 25 °C 2: dichloromethane / 25 °C / Inert atmosphere View Scheme

: 50-65-7
Niclosamide

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 1187819-29-9
4-chloro-2-((2-chloro-4-nitrophenyl)carbamoyl)phenyl dimethylcarbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran Reflux;	100%
With pyridine; dmap Reflux;

: 50-65-7
Niclosamide

: N-(4-amino-2-chloro-phenyl)-5-chloro-2-hydroxy-benzamide

Conditions

Conditions	Yield
With ammonium chloride; zinc In methanol at 0 - 20℃; for 16h;	100%
With ammonium chloride; zinc In methanol; water at 0 - 20℃; for 16h; Inert atmosphere;	100%
With palladium 10% on activated carbon; hydrogen In methanol; ethyl acetate at 20℃; under 3000.3 Torr; for 3h;	99.9%

: 50-65-7
Niclosamide

: 762-04-9
phosphonic acid diethyl ester

: 4-chloro-2-((2-chloro-4-nitrophenyl)carbamoyl)phenyl diethyl phosphate

Conditions

Conditions	Yield
With dmap; N-ethyl-N,N-diisopropylamine In tetrachloromethane; N,N-dimethyl-formamide at 0℃; for 2h;	96.2%

: 110-91-8
morpholine

: 50-00-0
formaldehyd

: 50-65-7
Niclosamide

: 860032-69-5
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-3-(morpholinomethyl)benzamide

Conditions

Conditions	Yield
In ethanol; water for 2h; Mannich reaction; Heating;	95%
In ethanol; water Mannich reaction; Reflux;	95%

...Expand

: 50-65-7
Niclosamide

: 74-88-4
methyl iodide

: 32060-31-4
5-chloro-N-(2-chloro-4-nitrophenyl)-2-methoxybenzamide

Conditions

Conditions	Yield
With potassium carbonate In acetone for 15h; Reflux; Sealed tube; Inert atmosphere;	94%

Total:200 Page 1 of 6 1 2 3 4 5 6 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 50-65-7

Chemistry

IUPAC Name: 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Empirical Formula: C₁₃H₈Cl₂N₂O₄
Molecular Weight: 327.1196g/mol
EINECS: 200-056-8
Structure of Niclosamide (CAS NO.50-65-7):

Index of Refraction: 1.709
Molar Refractivity: 79.04 cm³
Molar Volume: 202.4 cm³
Polarizability: 31.33×10^-24cm³
Surface Tension: 71.6 dyne/cm
Density: 1.615 g/cm³
Flash Point: 210.5 °C
Enthalpy of Vaporization: 70.52 kJ/mol
Boiling Point: 424.5 °C at 760 mmHg
Vapour Pressure: 8.35E-08 mmHg at 25°C
Product Categories: Veterinaries;API's
Canonical SMILES: C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
InChI: InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChIKey: RJMUSRYZPJIFPJ-UHFFFAOYSA-N

Uses

Niclosamide (CAS NO.50-65-7) is used as a piscicide.It is stressed that while anthelmintics are a drug family used to treat worm infections, Niclosamide is used specifically to treat tapeworms and is not effective against worms such as pinworms or roundworms.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD	oral	> 1gm/kg (1000mg/kg)		French Medicament Patent Document. Vol. #2628M,
mouse	LD50	intravenous	7500ug/kg (7.5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 884, 1960.
mouse	LD50	oral	1gm/kg (1000mg/kg)		"Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976.
rabbit	LD	oral	> 5gm/kg (5000mg/kg)		French Medicament Patent Document. Vol. #2628M,
rat	LD50	intraperitoneal	250mg/kg (250mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Zeitschrift fuer Tropenmedizin und Parasitologie. Vol. 13, Pg. 1, 1962.
rat	LD50	oral	2500mg/kg (2500mg/kg)		"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A297, Pg. 1983,

Safety Profile

RIDADR: UN 3077 9/PG 3
WGK Germany: 2
RTECS: VN8400000

Specification

Niclosamide , its cas register number is 50-65-7. It also can be called 2',5-Dichlor-4'-nitro-salizylsaeureanilid ; 2',5-Dichloro-4'-nitrosalicylanilide ; 2-Chloro-4-nitrophenylamide-6-chlorosalicylic acid ; 2-Hydroxy-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide ; 5-Chloro-2'-chloro-4'-nitrosalicylanilide ; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide ; 5-Chlorosalicyloyl-(o-chloro-p-nitranilide) ; Atenase ; Bayluscid ; Cestocid ; Devermine ; Dichlosale ; Fedal-Telmin ; Fenasal ; Helmiantin ; Lintex ; Mansonil ; Mato ; N-(2'-Chlor-4'-nitrophenyl)-5-chlorsalicylamid ; Nasemo ; Niclosamida ; Niclosamide ; Niclosamidum ; Nitrophenyl chlorsalicylamide ; Sagimid ; Salicylanilide, 2',5-dichloro-4'-nitro- ; Sulqui ; Vermitid ; Vermitin ;Yomesan ; Zestocarp .