European Journal of Medicinal Chemistry p. 509 - 514 (1995)
Update date:2022-08-05
Topics:
Kraouti, N.
Caujolle, R.
Labidalle, S.
Payard, M.
Loiseau, P. M.
et al.
A set of new analogs of pyrantel was synthesized in good yields by lithiation of 1,2-dimethyltetrahydropyrimidine with n-butyllithium in tetrahydrofuran and condensation with aromatic esters.Spetrometric studies showed the large influence of intra molecular bonding in the tautomeric equilibria between the possible structures.Anthelmintic screening showed in vitro efficiency against Molinema dessetae, but a weak activity against Rhabditis pseudoelongata and Nippostrongylus brasiliensis. tetrahydropyrimidine / pyrantel / tautomeric equilibrium/ nematocide
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