Synthesis of 2′-C-methyl ribonucleoside analogues with modified heterocyclic base moieties

Article abstract of DOI:10.1080/00397910903349984

Recently, 2′-C-methyl nucleoside analogues have been reported to exhibit potent anti-hepatitis C virus (HCV) activity through inhibition of HCV RNA replication without significant cytotoxicity. As a part of our continuous efforts of searching for novel antiviral agents, we now report the synthesis of heterobase-modified 2′-C-methyl ribonucleoside analogues. Copyright Taylor & Francis Group, LLC.