Chemistry - A European Journal p. 11365 - 11370 (2016)
Update date:2022-09-26
Topics:
Al-Shuaeeb, Riyadh Ahmed Atto
Kolodych, Sergii
Koniev, Oleksandr
Delacroix, Sébastien
Erb, Stéphane
Nicola?, Stéphanie
Cintrat, Jean-Christophe
Brion, Jean-Daniel
Cianférani, Sarah
Alami, Mouad
Wagner, Alain
Messaoudi, Samir
The third generation of aminobiphenyl palladacycle pre-catalyst “G3-Xantphos” enables functionalization of peptides containing cysteine in high yields. The conjugation (bioconjugation) occurs chemoselectively at room temperature under biocompatible conditions. Extension of the method to protein functionalization allows selective bioconjugation of the trastuzumab antibody.
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