Structure-activity relationships of benzimidazole-based selective inhibitors of the mitogen activated kinase-5 signaling pathway

DOI: 10.1016/j.bmc.2010.09.017

Source and publish data:

Bioorganic and Medicinal Chemistry p. 8054 - 8060 (2010)

Update date:2022-08-05

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Authors:

Flaherty, Patrick T.

Chopra, Ishveen

Jain, Prashi

Monlish, Darlene

Cavanaugh, Jane

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Article abstract of DOI:10.1016/j.bmc.2010.09.017

In a prior communication we identified a novel class of benzimidazole-based inhibitors of EGF-induced phosphorylation of ERK5. In this paper we examine the biological activity of several 1-isopropyl-4-amino-6-ether linked benzimidazole-based compounds for

Full text of DOI:10.1016/j.bmc.2010.09.017

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