Synthesis and molecular modelling of double-functionalised nucleosides with aromatic moieties in the 5′-(S)-position and minor groove interactions in DNA zipper structures

Article abstract of DOI:10.1002/chem.201001253

A series of six double-functionalised nucleosides, in which aromatic moieties were inserted into the 5?-(S)-C-position, were synthesised and incorporated into DNA duplexes. The aromatic moieties were thymine-1-yl, phenyl, 1,2,3-triazol-1-yl, 1,2,3-triazol