Synthesis and bioluminescence of electronically modified and rotationally restricted colour-shifting infraluciferin analogues

Article abstract of DOI:10.1016/j.tet.2018.11.061

Synthetic nIR emitting luciferins can enable clearer bioluminescent imaging in blood and tissue. A limiting factor for all synthetic luciferins is their reduced light output with respect to D-luciferin. In this work we explore a design feature of whether