REGIO- AND CHEMOSELECTIVE EPIMERIZATION OF cis-3-AMINO-β-LACTAMS TO THE trans-ISOMERS: A NEW SYNTHESIS OF AZTREONAM

DOI: 10.1016/S0040-4039(01)80522-0

Source and publish data:

Tetrahedron Letters p. 4837 - 4840 (1989)

Update date:2022-08-04

Topics:

Authors:

Kawabata, Takeo

Itoh, Kazuhiro

Hiyama, Tamejiro

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Article abstract of DOI:10.1016/S0040-4039(01)80522-0

The title isomerization reaction was effected with trifluoroacetic acid and shown to be applicable to the synthesis of an optically active monobactam antibiotic, aztreonam.

Full text of DOI:10.1016/S0040-4039(01)80522-0

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